Association of polymorphisms of IGF1R and genes in the transforming growth factor-β bone morphogenetic protein pathway with Bacteremia in sickle cell anemia

被引：35

作者：

Adewoye, Adeboye H.

Nolan, Vikki G.

Ma, Qianli

Baldwin, Clinton

Wyszynski, Diego F.

Farrell, John J.

Farrer, Lindsay A.

Steinberg, Martin H.

机构：

[1] Boston Univ, Sch Med, Dept Med, Boston, MA 02215 USA

[2] Boston Univ, Sch Med, Dept Pediat, Boston, MA 02215 USA

[3] Boston Univ, Sch Med, Ctr Human Genet, Boston, MA 02215 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2006年 / 43卷 / 05期

关键词：

D O I：

10.1086/506356

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Infection and bacteremia are common in sickle cell disease. We hypothesized that, consistent with evidence for the genetic modulation of other disease complications, the risk of developing bacteremia might also be genetically modulated. Accordingly, we studied the association of single nucleotide polymorphisms (SNPs) in candidate genes with the risk of bacteremia in sickle cell anemia. We found significant associations with SNPs in IGF1R and genes of the TGF-beta/BMP pathway (BMP6, TGFBR3, BMPR1A, SMAD6 and SMAD3). We suggest that both IGF1R and the TGF-beta/BMP pathway could play important roles in immune function in sickle cell anemia and their polymorphisms may help identify a "bacteremia-prone" phenotype.

引用

页码：593 / 598

页数：6

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