Quinazoline copper(II) ensemble as turn-on fluorescence sensor for cysteine and chemodosimeter for NO

被引：77

作者：

Anand, Thangaraj ^{[1
]}

Sivaraman, Gandhi ^{[1
]}

Chellappa, Duraisamy ^{[1
]}

机构：

[1] Madurai Kamaraj Univ, Sch Chem, Madurai 625021, Tamil Nadu, India

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY | 2014年 / 281卷

关键词：

Quinazoline; Copper(II); Cysteine; Nitric oxide; Off-On; TD-DFT; NITRIC-OXIDE DETECTION; COMPLEXES; CU(II); RECOGNITION; QUANTIFICATION; SPECTROMETRY; HOMOCYSTEINE; CHEMOSENSOR; REDUCTION; SEAWATER;

D O I：

10.1016/j.jphotochem.2014.02.015

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A fluorescent quinazoline based chemosensor QHYN had been designed and synthesized. It exhibits high sensitivity and selectivity towards Cu2+ over other metal ions in DMSO:H2O (1:9, v/v) at pH=7.4 [HEPES buffer] by fluorescence quenching. Addition of nitric oxide to a solution of this QHYN center dot Cu(II) restores the fluorescence. This is attributed to the reduction of the Cu(II) centre by nitric oxide to diamagnetic Cu(l). The fluorescence response of QHYN center dot Cu(II) to NO is direct and specific, which is a significant improvement over commercially available small molecule-based chemodosimeter probe that are capable of detecting NO. The QHYN center dot Cu(II) also acts as an efficient "off-on" fluorescent sensor for cysteine with high sensitivity. (c) 2014 Elsevier B.V. All rights reserved.

引用

页码：47 / 52

页数：6

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