Incidence of Hepatocellular Carcinoma in HIV-Infected Patients With Cirrhosis: A Prospective Study

被引：8

作者：

Montes Ramirez, Maria Luisa ^{[1
]}

Miro, Jose M. ^{[2
]}

Quereda, Carmen ^{[3
]}

Jou, Antoni ^{[4
,5
]}

Angel von Wichmann, Miguel ^{[6
]}

Berenguer, Juan ^{[7
]}

Gonzalez-Garcia, Juan J. ^{[1
]}

Hernando, Asuncion ^{[8
,9
]}

Ortega, Enrique ^{[10
]}

Sanz, Jose ^{[11
]}

Arribas, Jose R. ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Hosp Univ La Paz, HIV Unit, Serv Internal Med, Madrid, Spain

[2] Univ Barcelona, Hosp Clin IDIBAPS, Infect Dis Serv, Barcelona, Spain

[3] Hosp Ramon & Cajal, Infect Dis Serv, E-28034 Madrid, Spain

[4] Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol, Internal Med Dept, HIV Clin Unit, Barcelona, Spain

[5] Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol, Fundacio Lluita SIDA, Barcelona, Spain

[6] Hosp Donostia, Unit Infect Dis, Donostia San Sebastian, Spain

[7] Hosp Gen Univ Gregorio Maranon, Infect Dis & HIV Unit, Inst Invest Sanitaria Gregorio Maranon IiSGM, Madrid, Spain

[8] Hosp 12 Octubre, HIV Unit, E-28041 Madrid, Spain

[9] Univ Europea Madrid, Madrid, Spain

[10] Hosp Gen Univ Valencia, Infect Dis Unit, Valencia, Spain

[11] Hosp Univ Principe Asturias, Serv Internal Med, Madrid, Spain

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2014年 / 65卷 / 01期

关键词：

incidence; viral hepatitis; HIV; liver cirrhosis; hepatocellular carcinoma; HEPATITIS-C VIRUS; COINFECTED PATIENTS; LIVER-DISEASE; PROGRESSION; MORTALITY; FIBROSIS; COHORT; RISK;

D O I：

10.1097/QAI.0b013e3182a685dc

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study assesses the incidence of hepatocellular carcinoma (HCC) in a prospective cohort of HIV-infected patients, the majority receiving antiretroviral therapy, with liver cirrhosis from different etiologies, enrolled between 2004 and 2005 with median follow-up of 5 years. We followed 371 patients, 25.6% with decompensated cirrhosis at baseline. The incidence rate of HCC was 6.72 per 1000 person-years [95% confidence interval (CI): 2.6 to 10.9]. There was a trend toward a higher cumulative probability of developing HCC at 6 years of follow-up (considering death and liver transplant as competing risks) in patients with decompensated versus compensated cirrhosis at baseline (6% vs. 2%, P < 0.06).

引用

页码：82 / 86

页数：5

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