New class of antitubercular compounds: synthesis and anti-tubercular activity of 4-substituted pyrrolo[2,3-c]quinolines

被引：36

作者：

Akula, Mahesh ^{[1
]}

Sridevi, Jonnalagadda Padma ^{[2
]}

Yogeeswari, P. ^{[2
]}

Sriram, D. ^{[2
]}

Bhattacharya, Anupam ^{[1
]}

机构：

[1] Birla Inst Technol & Sci, Dept Chem, Hyderabad 500078, Andhra Pradesh, India

[2] Birla Inst Technol & Sci, Dept Pharm, Hyderabad 500078, Andhra Pradesh, India

来源：

MONATSHEFTE FUR CHEMIE | 2014年 / 145卷 / 05期

关键词：

Heterocycles; Strained molecules; Aldehydes; Mannich reaction; Antitubercular; PYRROLOQUINOLINE ALKALOIDS; BIOLOGICAL EVALUATION; IN-VITRO; MARINOQUINOLINES; DERIVATIVES; APLIDIOPSAMINE; ANALOGS;

D O I：

10.1007/s00706-013-1141-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Modified synthesis and antitubercular activity of 4-substituted pyrrolo[2,3-c]quinolines are reported. Some of the compounds showed significant antitubercular activity, when compared to some of the existing antitubercular drugs. A compound with an imidazole moiety at position 4 shows the highest activity and least toxicity.

引用

页码：811 / 819

页数：9

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