Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer's Disease

被引：22

作者：

Zhang, Ningnannan ^{[1
,2
]}

Song, Xiaowei ^{[1
,3
,4
]}

Bartha, Robert ^{[5
,6
]}

Beyea, Steven ^{[1
,4
,7
]}

D'Arcy, Ryan ^{[1
,8
,9
]}

Zhang, Yunting ^{[2
]}

Rockwood, Kenneth ^{[3
,10
]}

机构：

[1] Natl Res Council Canada, Inst Biodiagnost Atlantic, Halifax, NS, Canada

[2] Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin, Peoples R China

[3] Dalhousie Univ, Dept Med, Div Geriatr Med, Halifax, NS B3H 2E1, Canada

[4] Biomed Translat Imaging Ctr, Neuroimaging Res Lab, Halifax, NS, Canada

[5] Univ Western Ontario, Robarts Res Inst, Ctr Funct & Metab Mapping, London, ON, Canada

[6] Univ Western Ontario, Dept Med Biophys, London, ON, Canada

[7] Dalhousie Univ, Dept Phys, Halifax, NS B3H 2E1, Canada

[8] Simon Fraser Univ, Dept Appl Sci, Surrey, BC, Canada

[9] Fraser Hlth Fdn Innovat, Surrey Mem Hosp, Surrey, BC, Canada

[10] Queen Elizabeth 2 Hlth Sci Ctr, Ctr Hlth Care Elderly, Halifax, NS, Canada

来源：

CURRENT ALZHEIMER RESEARCH | 2014年 / 11卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Alzheimer's disease; brain; high-field; metabolite; mild cognitive impairment; neurochemical; proton magneticresonance spectroscopy; MILD COGNITIVE IMPAIRMENT; PROTON MR SPECTROSCOPY; VIVO H-1-NMR SPECTROSCOPY; N-ACETYL ASPARTATE; POSTERIOR CINGULATE GYRI; STRUCTURAL BRAIN CHANGES; SCYLLO-INOSITOL; ABSOLUTE QUANTIFICATION; CEREBROVASCULAR-DISEASE; ASSOCIATION WORKGROUPS;

D O I：

10.2174/1567205011666140302200312

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's disease (AD) affects several important molecules in brain metabolism. The resulting neurochemical changes can be quantified non-invasively in localized brain regions using in vivo single-voxel proton magnetic resonance spectroscopy (SV H-1 MRS). Although the often heralded diagnostic potential of MRS in AD largely remains unfulfilled, more recent use of high magnetic fields has led to significantly improved signal-to-noise ratios and spectral resolutions, thereby allowing clinical applications with increased measurement reliability. The present article provides a comprehensive review of SV 1H MRS studies on AD at high magnetic fields (3.0 Tesla and above). This review suggests that patterned regional differences and longitudinal alterations in several neurometabolites are associated with clinically established AD. Changes in multiple metabolites are identifiable even at early stages of AD development. By combining information of neurochemicals in different brain regions revealing either pathological or compensatory changes, high field MRS can be evaluated in AD diagnosis and in the detection of treatment effects. To achieve this, standardization of data acquisition and analytical approaches is needed.

引用

页码：367 / 388

页数：22

共 154 条

[1] Longitudinal decline of the neuronal marker N-acetyl aspartate in Alzheimer's disease [J].