Cellular redox homeostasis, reactive oxygen species and replicative ageing in Saccharomyces cerevisiae

被引:99
作者
Ayer, Anita [1 ,2 ]
Gourlay, Campbell W. [3 ]
Dawes, Ian W. [1 ]
机构
[1] Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia
[2] Victor Chang Cardiac Res Inst, Darlinghurst, NSW, Australia
[3] Univ Kent, Sch Biosci, Canterbury, Kent, England
关键词
replicative ageing; redox homeostasis; reactive oxygen species; OXIDATIVE-STRESS-RESPONSE; GLUTATHIONE-PEROXIDASE; LIFE-SPAN; DAMAGED PROTEINS; NADPH-OXIDASE; REDUCTASE; IN-VIVO; YEAST; CELLS; GENE;
D O I
10.1111/1567-1364.12114
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Ageing cells undergo changes in redox homeostasis and acquire high levels of reactive oxygen species (ROS). Because accumulation of ROS involves a change in redox state of cells, functions that are involved in setting redox and maintaining redox homeostasis are very relevant to an understanding of the possible roles of redox homeostasis and ROS in ageing. This review discusses these aspects of ROS in relation to replicative ageing in the model organism Saccharomyces cerevisiae, with reference to ROS generated in cells; cellular responses to oxidative stress; and how cells maintain redox homeostasis in different cellular compartments. It also considers when ROS generation begins as cells age, which ROS species are relevant to ageing and which cellular compartments and processes may contribute ROS to the ageing process. The discussion also covers the heterogeneity of cells with respect to ROS accumulation at particular cell ages, and the possibility of testing the oxidative theory of ageing in yeast cells.
引用
收藏
页码:60 / 72
页数:13
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