Study of complex coacervation of gelatin with sodium carboxymethyl guar gum: microencapsulation of clove oil and sulphamethoxazole

被引:56
作者
Thimma, RT [1 ]
Tammishetti, S [1 ]
机构
[1] Indian Inst Chem Technol, Organ Coatings & Polymers Div, Hyderabad 500007, Andhra Pradesh, India
关键词
complex coacervation; guar gum; microencapsulation; clove oil; sulphamethoxazole;
D O I
10.1080/0265204021000022789
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Complex coacervation of gelatin with sodium carboxymethyl guar gum was studied. The coacervation was studied as a function of pH, colloid composition and concentration. The efficiency of coacervation was followed by measuring viscosity, coacervate yield and turbidity of test solutions. All the measurements suggest that, as the amount of sodium carboxymethyl guar gum (CMGG) in the colloids increases, the pH at which maximum coacervation happens decreases. Effective coacervation could be realized over the pH range of 2.5-4.0 using different compositions. The efficiency of the CMGG/gelatin system to encapsulate oils and solid particles is demonstrated by successful encapsulation of oil of cloves and sulphmethoxazole.
引用
收藏
页码:203 / 210
页数:8
相关论文
共 15 条
[1]  
[Anonymous], 1973, IND GUMS POLYSACCHAR
[2]  
*ASTM, 1978, 1978 ANN BOOK AST 28, P298
[3]  
Bungenberg de Jong HG, 1949, COLLOID SCI, VII, P431
[4]   CHARACTERIZATION OF ALBUMIN-ACACIA COMPLEX COACERVATION [J].
BURGESS, DJ ;
KWOK, KK ;
MEGREMIS, PT .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1991, 43 (04) :232-236
[5]   Use of gelatin-acacia coacervate containing benzocaine in topical formulations [J].
Ichwan, AM ;
Karimi, M ;
Dash, AK .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1999, 88 (08) :763-766
[6]   CHARACTERIZATION OF SODIUM CARBOXYMETHYLCELLULOSE-GELATIN COMPLEX COACERVATION BY VISCOSITY, TURBIDITY AND COACERVATE WET WEIGHT AND VOLUME MEASUREMENTS [J].
KOH, GL ;
TUCKER, IG .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1988, 40 (04) :233-236
[7]   CHARACTERIZATION OF SODIUM CARBOXYMETHYLCELLULOSE-GELATIN COMPLEX COACERVATION BY CHEMICAL-ANALYSIS OF THE COACERVATE AND EQUILIBRIUM FLUID PHASES [J].
KOH, GL ;
TUCKER, IG .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1988, 40 (05) :309-312
[8]  
LENK T, 1986, ACS SYM SER, V302, P240
[9]   PECTIN GELATIN COMPLEX COACERVATES .1. DETERMINANTS OF MICROGLOBULE SIZE, MORPHOLOGY, AND RECOVERY AS WATER-DISPERSIBLE POWDERS [J].
MCMULLEN, JN ;
NEWTON, DW ;
BECKER, CH .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1982, 71 (06) :628-633
[10]   The influence of HLB on the encapsulation of oils by complex coacervation [J].
Rabiskova, M ;
Valaskova, J .
JOURNAL OF MICROENCAPSULATION, 1998, 15 (06) :747-751