Myc's other life: stem cells and beyond

被引：81
作者：
Laurenti, Elisa [3 ]
Wilson, Anne [3 ]
Trumpp, Andreas [1 ,2 ]
机构：
[1] German Canc Res Ctr, Div Stem Cells & Canc, D-69120 Heidelberg, Germany
[2] HI STEM Heidelberg Inst Stem Cell Technol & Expt, D-69120 Heidelberg, Germany
[3] Univ Lausanne, Ludwig Inst Canc Res Ltd, Lausanne Branch, CH-1015 Lausanne, Switzerland
来源：
CURRENT OPINION IN CELL BIOLOGY | 2009年 / 21卷 / 06期
关键词：
FBW7 UBIQUITIN LIGASE; C-MYC; N-MYC; SELF-RENEWAL; HUMAN GENOME; TRANSCRIPTIONAL ACTIVATION; TARGETED DISRUPTION; EMBRYONIC LETHALITY; NEURAL PRECURSORS; INTESTINAL CRYPTS;
D O I：
10.1016/j.ceb.2009.09.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Over the last three decades genetic and biochemical studies have revealed the pleiotropic effects of the Myc oncoprotein. While cell line studies have defined the intracellular processes regulated by Myc such as proliferation, differentiation, and metabolic growth, in vivo studies have confirmed these functions, and revealed roles in acquisition and maintenance of stem cell properties. These roles may be partially mediated by Myc's capacity to modify the chromatin landscape on a global scale. Myc also regulates numerous protein-coding transcripts, and many noncoding RNAs (rRNAs, tRNAs, and miRNAs). As Myc activity directly correlates with protein expression, further complexity is provided by post-translational modifications that regulate Myc in normal stem cells or deregulate it in malignant stem cells.
引用
收藏
页码：844 / 854
页数：11
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