Hereditary Colorectal Cancer Syndromes

被引：49

作者：

Wells, Katerina ^{[1
]}

Wise, Paul E. ^{[2
]}

机构：

[1] Baylor Univ, Med Ctr, Dept Surg, Div Colon & Rectal Surg, 3409 Worth St,Suite 640, Dallas, TX 75246 USA

[2] Washington Univ, Inherited Colorectal Canc & Polyposis Registry, Sect Colon & Rectal Surg, Div Gen Surg,Sch Med, Gen Surg Residency,660 South Euclid Ave, St Louis, MO 63110 USA

来源：

SURGICAL CLINICS OF NORTH AMERICA | 2017年 / 97卷 / 03期

关键词：

Inherited colon cancer; Hereditary nonpolyposis colorectal cancer; Lynch syndrome; Familial adenomatous polyposis; MUTYH-associated polyposis; Serrated polyposis syndrome; FAMILIAL ADENOMATOUS POLYPOSIS; POUCH-ANAL ANASTOMOSIS; LYNCH-SYNDROME; MISMATCH-REPAIR; MICROSATELLITE INSTABILITY; GASTROINTESTINAL CANCER; GERMLINE MUTATIONS; CLINICAL-CRITERIA; COLON-CANCER; RISK-FACTORS;

D O I：

10.1016/j.suc.2017.01.009

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Awareness of hereditary colorectal cancer syndromes is important to facilitate their identification because affected patients are at increased risk for early onset, synchronous, and metachronous colorectal malignancies, and certain extracolonic malignancies depending on the syndrome. Identification of an affected individual allows for screening and early interventions for patients and their at-risk kindred. Genetic counseling and testing is important to the care of these patients. As knowledge of the genetic basis of these syndromes grows, unique genotype-phenotype profiles allow clinicians to tailor surveillance and treatment strategies based on individual risk.

引用

页码：605 / +

页数：22

共 95 条

[1] Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors [J].