Effects of estrogen on skeletal myoblast growth

被引：87
作者：
Kahlert, S
Grohe, C
Karas, RH
Lobbert, K
Neyses, L
Vetter, H
机构：
[1] UNIV BONN, MED POLIKLIN, D-53111 BONN, GERMANY
[2] TUFTS UNIV, NEW ENGLAND MED CTR, SCH MED, MOL CARDIOL RES CTR, BOSTON, MA 02111 USA
[3] UNIV WURZBURG, MED KLIN, D-97080 WURZBURG, GERMANY
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 232卷 / 02期
关键词：
D O I：
10.1006/bbrc.1997.6223
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To determine the role of estrogen in skeletal muscle growth, we investigated estrogen receptor-mediated effects on proliferation in skeletal myoblasts. In L6, C2C12 and Sol8 myoblasts estrogen receptor was demonstrated by immunoblotting, immunofluorescence microscopy and transfection studies. Estrone induced a significant increase in myoblast growth whereas 17 beta-estradiol had no effect. Furthermore in L6-cells estrone (c-fos: 3.9-fold, egr-1: 4.6-fold) induced immediate-early gene induction significantly stronger than 17 beta-estradiol (c-fos: 1.7-fold, egr-1: 2.3-fold; p<0.05). Skeletal myoblasts express functional estrogen receptors. Estrogens differ in the activation of skeletal myoblast growth and immediate-early gene induction. (C) 1997 Academic Press.
引用
收藏
页码：373 / 378
页数：6
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