Mechanisms involved in the therapeutic properties of mesenchymal stem cells

被引：1060

作者：

Meirelles, Lindolfo da Silva ^{[2
]}

Fontes, Aparecida Maria ^{[2
]}

Covas, Dimas Tadeu ^{[2
,3
]}

Caplan, Arnold I. ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Biol, Skeletal Res Ctr, Millis Sci Ctr, Cleveland, OH 44106 USA

[2] Univ Sao Paulo, Natl Inst Sci & Technol Stem Cells & Cell Therapy, Ctr Reg Hemoterapia Ribeirao Preto, HCFMRP, BR-14051140 Ribeirao Preto, SP, Brazil

[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Clin Med, BR-14048900 Ribeirao Preto, SP, Brazil

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2009年 / 20卷 / 5-6期

基金：

巴西圣保罗研究基金会; 美国国家卫生研究院;

关键词：

Mesenchymal stem cell; Pericyte; Therapeutics; Homing; Cell therapy; HUMAN BONE-MARROW; T-LYMPHOCYTE PROLIFERATION; ADIPOSE STROMAL CELLS; PROGENITOR CELLS; IN-VITRO; GENE-EXPRESSION; MICROVASCULAR PERICYTES; INTERNATIONAL-SOCIETY; PERIVASCULAR CELLS; POSITION STATEMENT;

D O I：

10.1016/j.cytogfr.2009.10.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mesenchymal stem cells (MSCs) have been described as being able to give rise to several quite different mesenchymal cell phenotypes. However, the ability to differentiate is not the only characteristic that makes these cells attractive for therapeutic purposes. The secretion of a broad range of bioactive molecules by MSCs, such as growth factors, cytokines and chemokines, constitutes their most biologically significant role under injury conditions. Understanding this intricate secretory activity as well as the properties of MSCs in vivo is central to harnessing their clinical potential. Herein, we identify some of the molecules involved in the paracrine effects of MSCs with a perspective that these cells intrinsically belong to a perivascular niche in vivo, and discuss how this knowledge could be advantageously used in clinical applications. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：419 / 427

页数：9

共 97 条

[1] Human mesenchymal stem cells modulate allogeneic immune cell responses [J].