Apo2L/TRAIL and immune regulation

被引：34

作者：

Anel, Alberto ^{[1
]}

Bosque, Alberto

Naval, Javier

Pineiro, Andres

Larrad, Luis

Angeles Alava, Maria

Jose Martinez-Lorenzo, Maria

机构：

[1] Univ Zaragoza, Fac Ciencias, Dept Bioquim & Biol Mol & Celular, E-50009 Zaragoza, Spain

[2] Univ Zaragoza, Univ Clin Hosp, Inst Hlth Sci Aragon, E-50009 Zaragoza, Spain

[3] Univ Zaragoza, Univ Clin Hosp, Serv Immunol, E-50009 Zaragoza, Spain

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2007年 / 12卷

关键词：

Apo2L/TRAIL; immune regulation; autoimmune disease; review;

D O I：

10.2741/2212

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apo2L/TRAIL is a member of the TNF family, with its receptors DR4 and DR5 containing a death domain. Multiple tumors are sensitive to Apo2L/TRAIL-induced apoptosis, while normal cells are not, so it constitutes a promising new antitumoral therapy. In this review we deal rather with the physiological role of Apo2L/TRAIL, which, in one hand, is clearly related with immune antitumoral surveillance. However, a role of Apo2L/TRAIL as a fine-tuning regulator of the immune system, especially in the regulation of CD8(+) T cell activation and memory, has been also demonstrated. In fact, Apo2L/TRAIL can be considered as an additional mechanism needed to prevent the development of autoimmune disease. Indeed, recent developments indicate that Apo2L/TRAIL can be also useful as a treatment against certain chronic autoimmune diseases.

引用

页码：2074 / 2084

页数：11

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