Development of Aplastic Anemia during Treatment of Anaplastic Astrocytoma with Temozolomide

被引：1

作者：

Khaddour, Karam ^{[1
]}

Harrison, Nigel ^{[2
]}

Govindan, Ashwin ^{[1
]}

Campian, Jian L. ^{[1
]}

机构：

[1] Washington Univ, Div Oncol, St Louis, MO 63110 USA

[2] Washington Univ, Div Neurol, St Louis, MO 63110 USA

来源：

CASE REPORTS IN ONCOLOGY | 2020年 / 13卷 / 03期

关键词：

Temozolomide; Aplastic anemia; Bone marrow; Anaplastic astrocytoma; Glioblastoma; PATIENT; RISK;

D O I：

10.1159/000509744

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Temozolomide (TMZ) is an oral alkylating agent that is considered the standard therapy in primary intracranial malignancies. The medication is well tolerated with a most common side effect of bone marrow suppression that is encountered in a small proportion of patients, often reversible with medication discontinuation and supportive treatment. Rarely, aplastic anemia can develop during treatment with TMZ. Here, we present a case of a patient who developed aplastic anemia following treatment with TMZ. We offer a review of the existing literature to have a better understanding of the causative effect and to examine the characteristics and outcomes when aplastic anemia develops during treatment with TMZ.

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收藏

页码：1244 / 1251

页数：8

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