Cerebrovascular reactivity measurements using simultaneous 15O-water PET and ASL MRI: Impacts of arterial transit time, labeling efficiency, and hematocrit

被引：37

作者：

Zhao, Moss Y. ^{[1
]}

Fan, Audrey P. ^{[2
,3
]}

Chen, David Yen-Ting ^{[4
,5
]}

Sokolska, Magdalena J. ^{[6
]}

Guo, Jia ^{[7
]}

Ishii, Yosuke ^{[8
]}

Shin, David D. ^{[9
]}

Khalighi, Mohammad Mehdi ^{[1
]}

Holley, Dawn ^{[1
]}

Halbert, Kim ^{[1
]}

Otte, Andrea ^{[1
]}

Williams, Brittney ^{[1
]}

Rostami, Taghi ^{[10
]}

Park, Jun-Hyung ^{[1
]}

Shen, Bin ^{[1
]}

Zaharchuk, Greg ^{[1
]}

机构：

[1] Stanford Univ, Dept Radiol, Stanford, CA 94305 USA

[2] Univ Calif Davis, Dept Biomed Engn, Davis, CA 95616 USA

[3] Univ Calif Davis, Dept Neurol, Davis, CA 95616 USA

[4] Taipei Med Univ, Shuan Ho Hosp, Dept Med Imaging, New Taipei, Taiwan

[5] Taipei Med Univ, Coll Med, Sch Med, Dept Radiol, Taipei, Taiwan

[6] Univ Coll London Hosp, Med Phys & Biomed Engn, London, England

[7] Univ Calif Riverside, Dept Bioengn, Riverside, CA 92521 USA

[8] Tokyo Med & Dent Univ, Dept Neurosurg, Tokyo, Japan

[9] GE Healthcare, Menlo Pk, CA USA

[10] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

来源：

NEUROIMAGE | 2021年 / 233卷

关键词：

Cerebrovascular reactivity; Cerebrovascular reserve; Cerebral blood flow; Positron emission tomography; Magnetic resonance imaging; Pseudo-continuous arterial spin labeling; Velocity selective arterial spin labeling; PET; MRI; CEREBRAL-BLOOD-FLOW; BREATH-HOLD TASK; PERFUSION; REPRODUCIBILITY; INVERSION; INFERENCE; SENSITIVITY; STENOSIS; RESERVE; DISEASE;

D O I：

10.1016/j.neuroimage.2021.117955

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cerebrovascular reactivity (CVR) reflects the capacity of the brain to meet changing physiological demands and can predict the risk of cerebrovascular diseases. CVR can be obtained by measuring the change in cerebral blood flow (CBF) during a brain stress test where CBF is altered by a vasodilator such as acetazolamide. Although the gold standard to quantify CBF is PET imaging, the procedure is invasive and inaccessible to most patients. Arterial spin labeling (ASL) is a non-invasive and quantitative MRI method to measure CBF, and a consensus guideline has been published for the clinical application of ASL. Despite single post labeling delay (PLD) pseudo-continuous ASL (PCASL) being the recommended ASL technique for CBF quantification, it is sensitive to variations to the arterial transit time (ATT) and labeling efficiency induced by the vasodilator in CVR studies. Multi-PLD ASL controls for the changes in ATT, and velocity selective ASL is in theory insensitive to both ATT and labeling efficiency. Here we investigate CVR using simultaneous 15 O-water PET and ASL MRI data from 19 healthy subjects. CVR and CBF measured by the ASL techniques were compared using PET as the reference technique. The impacts of blood T1 and labeling efficiency on ASL were assessed using individual measurements of hematocrit and flow velocity data of the carotid and vertebral arteries measured using phase-contrast MRI. We found that multi-PLD PCASL is the ASL technique most consistent with PET for CVR quantification (group mean CVR of the whole brain = 42 ? 19% and 40 ? 18% respectively). Single-PLD ASL underestimated the CVR of the whole brain significantly by 15 ? 10% compared with PET ( p < 0.01, paired t-test). Changes in ATT pre-and post-acetazolamide was the principal factor affecting ASL-based CVR quantification. Variations in labeling efficiency and blood T1 had negligible effects.

引用

页数：17

共 64 条

[1] The Effect of Daily Caffeine Use on Cerebral Blood Flow: How Much Caffeine can we Tolerate? [J].