Recapitulating human myogenesis ex vivo using human pluripotent stem cells

被引:3
作者
Chien, Peggie [1 ]
Xi, Haibin [1 ]
Pyle, April D. [1 ]
机构
[1] Univ Calif Los Angeles, Mol Biol Inst, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
关键词
human myogenesis; human pluripotent stem cells; muscle stem and progenitor cells; development; cell differentiation; HEAVY-CHAIN EXPRESSION; WNT SIGNALING CONTROLS; SKELETAL-MUSCLE; VERTEBRATE MYOGENESIS; PROGENITOR CELLS; PARAXIAL MESODERM; GENE-EXPRESSION; CLONAL ANALYSIS; SONIC HEDGEHOG; IN-VITRO;
D O I
10.1016/j.yexcr.2021.112990
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Human pluripotent stem cells (hPSCs) provide a human model for developmental myogenesis, disease modeling and development of therapeutics. Differentiation of hPSCs into muscle stem cells has the potential to provide a cell-based therapy for many skeletal muscle wasting diseases. This review describes the current state of hPSCs towards recapitulating human myogenesis ex vivo, considerations of stem cell and progenitor cell state as well as function for future use of hPSC-derived muscle cells in regenerative medicine.
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页数:8
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