Enzyme catalyzed hydroxymethylation of aromatic aldehydes with formaldehyde.: Synthesis of hydroxyacetophenones and (S)-benzoins

被引：33

作者：

Demir, AS ^{[1
]}

Ayhan, P ^{[1
]}

Igdir, AC ^{[1
]}

Duygu, AN ^{[1
]}

机构：

[1] Middle E Tech Univ, Dept Chem, TR-06531 Ankara, Turkey

来源：

TETRAHEDRON | 2004年 / 60卷 / 31期

关键词：

hydroxymethylation; hydroxy ketones; carboligation; enzyme catalysis; benzoin;

D O I：

10.1016/j.tet.2004.06.015

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Benzaldehyde lyase from the Pseudomonas Fluorescens catalyzed reaction of aromatic aldehydes with formaldehyde providing 2-hydroxy-1-arylethan-1-one in high yields via an acyloin linkage. Kinetic resolution of rac-benzoins with formaldehyde providing (S)-benzoins and 2-hydroxy-1-arylethan-1-one via C-C bond cleavage and a bond formation reaction. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：6509 / 6512

页数：4

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