Neuroplasticity in post-stroke gait recovery and noninvasive brain stimulation

被引：22

作者：

Xu, Yi ^{[1
,2
,3
]}

Hou, Qing-hua ^{[4
]}

Russell, Shawn D. ^{[3
]}

Bennett, Bradford C. ^{[5
]}

Sellers, Andrew J. ^{[6
]}

Lin, Qiang ^{[1
,2
]}

Huang, Dong-feng ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Rehabil Med, Guangzhou 510275, Guangdong, Peoples R China

[2] Guangdong Prov Engn Technol Res Ctr Rehabil Med &, Guangzhou, Guangdong, Peoples R China

[3] Univ Virginia, Dept Orthoped & Mech Engn, Mot Anal & Motor Performance Lab, Charlottesville, VA USA

[4] Guangdong 2 Prov Peoples Hosp, Dept Neurol, Guangzhou, Guangdong, Peoples R China

[5] Northwestern Hlth Sci Univ, HC Sweere Ctr Clin Biomech & Appl Ergon, Bloomington, MN USA

[6] Naval Med Ctr Portsmouth, Dept Radiol, Portsmouth, VA USA

来源：

NEURAL REGENERATION RESEARCH | 2015年 / 10卷 / 12期

基金：

中国国家自然科学基金;

关键词：

nerve regeneration; stroke; cerebrovascular disorders; transcranial magnetic stimulation; neuroplasticity; transcranial direct current stimulation; electrical stimulation therapy; gait; walking; gait disorders; rehabilitation; neural regeneration; TRANSCRANIAL MAGNETIC STIMULATION; PRIMARY MOTOR CORTEX; SPINAL-CORD; CEREBRAL-CORTEX; CHRONIC STROKE; FUNCTIONAL REORGANIZATION; CORTICAL EXCITABILITY; EXCITATORY CIRCUITS; LOCOMOTOR RECOVERY; SKILL ACQUISITION;

D O I：

10.4103/1673-5374.172329

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Gait disorders drastically affect the quality of life of stroke survivors, making post-stroke rehabilitation an important research focus. Noninvasive brain stimulation has potential in facilitating neuroplasticity and improving post-stroke gait impairment. However, a large inter-individual variability in the response to noninvasive brain stimulation interventions has been increasingly recognized. We first review the neurophysiology of human gait and post-stroke neuroplasticity for gait recovery, and then discuss how noninvasive brain stimulation techniques could be utilized to enhance gait recovery. While post-stroke neuroplasticity for gait recovery is characterized by use-dependent plasticity, it evolves over time, is idiosyncratic, and may develop maladaptive elements. Furthermore, noninvasive brain stimulation has limited reach capability and is facilitative-only in nature. Therefore, we recommend that noninvasive brain stimulation be used adjunctively with rehabilitation training and other concurrent neuroplasticity facilitation techniques. Additionally, when noninvasive brain stimulation is applied for the rehabilitation of gait impairment in stroke survivors, stimulation montages should be customized according to the specific types of neuroplasticity found in each individual. This could be done using multiple mapping techniques.

引用

页码：2072 / 2080

页数：9

共 97 条

[1] Deterioration of pre-existing hemiparesis brought about by subsequent ipsilateral lacunar infarction [J].

Ago, T ;

Kitazono, T ;

Ooboshi, H ;

Takada, J ;

Yoshiura, T ;

Mihara, F ;

Ibayashi, S ;

Iida, M .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2003, 74 (08) :1152-1153

[2] Can stroke patients walk after complete lateral corticospinal tract injury of the affected hemisphere? [J].

Ahn, Young Hwan ;

Ahn, Sang Ho ;

Kim, Hoeon ;

Hong, Ji Hun ;

Jang, Sung Ho .

NEUROREPORT, 2006, 17 (10) :987-990

[3] Differential Effects of High-Frequency Repetitive Transcranial Magnetic Stimulation Over Ipsilesional Primary Motor Cortex in Cortical and Subcortical Middle Cerebral Artery Stroke [J].

Ameli, Mitra ;

Grefkes, Christian ;

Kemper, Friederike ;

Riegg, Florian P. ;

Rehme, Anne K. ;

Karbe, Hans ;

Fink, Gereon R. ;

Nowak, Dennis A. .

ANNALS OF NEUROLOGY, 2009, 66 (03) :298-309

[4] Phase Locking Asymmetries at Flexor-Extensor Transitions during Fictive Locomotion [J].

Boothe, David L. ;

Cohen, Avis H. ;

Troyer, Todd W. .

PLOS ONE, 2013, 8 (05)

[5] Contrasting properties of motor output from the supplementary motor area and primary motor cortex in rhesus macaques [J].

Boudrias, MH ;

Belhaj-Saïf, A ;

Park, MC ;

Cheney, PD .

CEREBRAL CORTEX, 2006, 16 (05) :632-638

[6] Distributed Versus Focal Cortical Stimulation to Enhance Motor Function and Motor Map Plasticity in a Rodent Model of Ischemia [J].

Boychuk, Jeffery A. ;

Adkins, DeAnna L. ;

Kleim, Jeffrey A. .

NEUROREHABILITATION AND NEURAL REPAIR, 2011, 25 (01) :88-97

[7] Motor learning after stroke: Is skill acquisition a prerequisite for contralesional neuroplastic change? [J].

Boyd, Lara A. ;

Vidoni, Eric D. ;

Wessel, Brenda D. .

NEUROSCIENCE LETTERS, 2010, 482 (01) :21-25

[8] In Vivo Voltage-Sensitive Dye Imaging in Adult Mice Reveals That Somatosensory Maps Lost to Stroke Are Replaced over Weeks by New Structural and Functional Circuits with Prolonged Modes of Activation within Both the Peri-Infarct Zone and Distant Sites [J].

Brown, Craig E. ;

Aminoltejari, Khatereh ;

Erb, Heidi ;

Winship, Ian R. ;

Murphy, Timothy H. .

JOURNAL OF NEUROSCIENCE, 2009, 29 (06) :1719-1734

[9] Studies on the corticospinal control of human walking. I. Responses to focal transcranial magnetic stimulation of the motor cortex [J].

Capaday, C ;

Lavoie, BA ;

Barbeau, H ;

Schneider, C ;

Bonnard, M .

JOURNAL OF NEUROPHYSIOLOGY, 1999, 81 (01) :129-139

[10] New patterns of intracortical projections after focal cortical stroke [J].

Carmichael, ST ;

Wei, L ;

Rovainen, CM ;

Woolsey, TA .

NEUROBIOLOGY OF DISEASE, 2001, 8 (05) :910-922

← 1 2 3 4 5 6 7 8 9 10 →