Quantitative Assessment of Tumor Cell Proliferation in Brain Gliomas with Dynamic Contrast-Enhanced MRI

被引:17
作者
Jiang, Jia Shen [1 ]
Hua, Ye [1 ]
Zhou, Xue Jun [1 ]
Shen, Dan Dan [1 ]
Shi, Jin Long [2 ]
Ge, Min [1 ]
Geng, Qi Nan [1 ]
Jia, Zhong Zheng [1 ]
机构
[1] Nantong Univ, Affiliated Hosp, Dept Med Imaging, 20 Xisi Rd, Nantong 226001, Jiangsu, Peoples R China
[2] Nantong Univ, Affiliated Hosp, Dept Neurosurg, Nantong, Jiangsu, Peoples R China
基金
中国博士后科学基金;
关键词
Glioma; Magnetic resonance imaging; Dynamic contrast-enhanced; Ki-67; KI-67 LABELING INDEX; MICROVASCULAR PERMEABILITY; HISTOLOGIC GRADE; DCE-MRI; EXPRESSION; MIB-1; CLASSIFICATION; PARAMETERS; SURVIVAL; REVEALS;
D O I
10.1016/j.acra.2018.10.012
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Rationale and Objectives: This study aimed to investigate whether volume transfer constant (K-trans) and volume of extravascular extracellular space per unit volume of tissue (V-e) derived from dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) could quantitatively assess the tumor proliferation index (KI-67) of gliomas non invasively. Materials and Methods: The preoperative DCE MRI data of 69 patients with pathologically confirmed glioma (28, 8, and 33 cases in grades II, III, and IV) were retrospectively reviewed. The maximal K (trans) and V-e were measured in the tumor body. The immunohistochemistry was used to detect the expression of Ki-67 proteins in glioma specimens. The Mann-Whitney U test was applied to analyze the differences in K-trans, V-e, and Ki-67 index across histologically defined glioma grades. Spearman correlation was performed between K-trans, V-e, and Ki-67 index. The receiver operating characteristic curve analysis was used to determine the cutoff values of K-trans and V-e in distinguishing different Ki-67 index expression levels. Results: K-trans, V-e, and Ki-67 index of grade II (0.027 min(-1), 0.065, 4.04%) were significantly lower than those of grade III (0.093 min(-1), 0.297, 25.13%) and IV (0.100 min(-1), 0.299, 25.37%). Both K-trans and V-e significantly correlated with the Ki-67 index in all tumors and high-grade gliomas (HGGs, grade III and IV). The receiver operating characteristic curve analysis revealed that the cutoff values for K-trans (0.079 min(-1)) and V-e (0.249) provided the best combination of sensitivity and specificity to distinguish the gliomas with high Ki-67 index from those with low Ki-67 index. Conclusion: The DCE MRI-derived parameters were valuable in assessing the tumor cell proliferation in HGG noninvasively.
引用
收藏
页码:1215 / 1221
页数:7
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