Differences in the Transmission of Dengue Fever by Different Serotypes of Dengue Virus

被引：12

作者：

Niu, Cong ^{[1
,2
]}

Huang, Yalan ^{[1
]}

Wang, Miao ^{[1
]}

Huang, Dana ^{[1
]}

Li, Jia ^{[2
]}

Huang, Suibin ^{[1
]}

Yang, Fan ^{[1
]}

Wan, Chengsong ^{[2
]}

Zhang, Renli ^{[1
]}

机构：

[1] Shenzhen Ctr Dis Control & Prevent, Dept Microorganism Examinat, 8 Longyuan Rd, Shenzhen 518055, Peoples R China

[2] Southern Med Univ, Sch Publ Hlth, 1023 Shatai South Rd, Guangzhou 510515, Guangdong, Peoples R China

来源：

VECTOR-BORNE AND ZOONOTIC DISEASES | 2020年 / 20卷 / 02期

基金：

中国国家自然科学基金;

关键词：

dengue virus; NS1; protein; viral replication; Aedes albopictus; Aedes aegypti; ENHANCEMENT; INFECTION;

D O I：

10.1089/vbz.2019.2477

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Dengue fever is the most common arbovirus in the world, and all four serotypes are infectious and pathogenic, but dengue virus (DENV)-1 and DENV-2 are the most prevalent in Guangdong Province. To investigate the differences in serotypes, we evaluated the replication, pathogenicity, and NS1 expression of DENV-2 and DENV-3 in cells, and further investigated the effects of NS1 on viral replication and transmission. The results of this study indicated that DENV-2 replicated faster and was more pathogenic than DENV-3. In Vero cells, DENV-2 secreted more NS1 protein than DENV-3, and NS1 protein promoted the infection of Aedes albopictus and A. aegypti by DENV. The spread of DENV and the severity of the disease depend on many factors. Further research on the differences between different serotypes of DENV will help us understand the epidemiology of DENV infection. This will provide a scientific basis for the prevention and control of the dengue epidemic.

引用

页码：143 / 150

页数：8

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