Evaluation of the epidemiological and prognosis significance of ESR2 rs3020450 polymorphism in ovarian cancer

被引：4
作者：
Feng, Yajing [1 ,5 ]
Peng, Zhen [4 ]
Liu, Weigang [3 ]
Yang, Zhongyu [6 ]
Shang, Jia [4 ]
Cui, Liuxin [1 ]
Duan, Fujiao [1 ,2 ]
机构：
[1] Zhengzhou Univ, Coll Publ Hlth, Zhengzhou, Henan, Peoples R China
[2] Zhengzhou Univ, Affiliated Canc Hosp, Med Res Off, Zhengzhou, Henan, Peoples R China
[3] Hebei Univ Engn, Affiliated Hosp, Med Record Stat Off, Handan, Hebei, Peoples R China
[4] Zhengzhou Univ, Henan Prov Peoples Hosp, Peoples Hosp, Dept Infect Dis, Zhengzhou, Henan, Peoples R China
[5] Zhengzhou Univ, Affiliated Hosp 1, Dept Nosocomial Infect Management, Zhengzhou, Henan, Peoples R China
[6] Ohio State Univ, Coll Art & Sci, Columbus, OH 43210 USA
来源：
GENE | 2019年 / 710卷
基金：
中国国家自然科学基金;
关键词：
ESR2; Ovarian cancer; Polymorphism; Epidemiological evaluation; Prognosis; ESTROGEN-RECEPTOR-BETA; BREAST-CANCER; GENE POLYMORPHISMS; PROMOTER REGION; ATTRIBUTABLE RISK; ER-BETA; EXPRESSION; ASSOCIATION; ALPHA; SUSCEPTIBILITY;
D O I：
10.1016/j.gene.2019.06.017
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aim: To investigate the correlation between the polymorphism of estrogen receptor beta gene (ESR2) rs3020450 and cancer susceptibility, and explore the epidemiological significance and the effect of ESR2 expression levels on the prognosis of ovarian cancer. Methods: Based on meta-analysis the association between ESR2 rs3020450 polymorphism and cancer susceptibility was estimated and a case-control design was used to verify this result in ovarian cancer. The epidemiological effect of ESR2 rs3020450 polymorphism was assessed by attributable risk percentage (ARP) and population attributable risk percentage (PARP). Kaplan Meier plotters were used to evaluate overall survival (OS) and progression-free survival (PFS) in ovarian cancer patients and GEPIA for the differential expression of ESR2 levels in ovarian cancer and adjacent normal tissues. Results: The pooled analysis indicated no significant correlation between the ESR2 rs3020450 polymorphism and the cancer susceptibility. In the stratified analysis by cancer types, significantly decreased risk was found in ovarian cancer (AG vs GG: OR = 0.73, 95%CI: 0.53-0.97, P = 0.03). Unconditional logistic regression results of case-control study in ovarian cancer observed significant differences in all comparisons (AG vs GG: OR = 0.81, 95%CI: 0.62-0.98, P = 0.04; AA vs GG: OR = 0.63, 95%CI: 0.42-0.92, P = 0.01 and AG + AA vs GG: OR = 0.73, 95%CI: 0.53-0.96, P < 0.001). Based on meta-analysis and case-control pooled results, ARP and PARP were evaluated respectively in allele (21.95% and7.97%), heterozygote (36.99% and 12.11%) and dominant model (36.84% and 12.97%) of rs3020450 polymorphism in ovarian cancer. The expression levels of ESR2 in normal tissues was significantly higher than that in cancer tissues (OV, Median, 4.7:0.21), and significant correlations were observed between high ESR2 expression levels and long OS (HR = 0.80, 95%CI: 0.70-0.92, P = 0.002) and PFS (HR = 0.767, 95%CI: 0.67-0.88, P < 0.001). Conclusion: Our results indicated that ESR2 rs3020450 polymorphism was associated with ovarian cancer risk from epidemiological perspective, and high ESR2 expression levels was associated with long survival in patients with ovarian cancer.
引用
收藏
页码：316 / 323
页数：8
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