Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]-4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279):: A very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes

被引:39
|
作者
Madar, David J. [1 ]
Kopecka, Hana [1 ]
Pireh, Daisy [1 ]
Yong, Hong [1 ]
Pei, Zhonghua [1 ]
Li, Xiaofeng [1 ]
Wiedeman, Paul E. [1 ]
Djuric, Stevan W. [1 ]
Von Geldern, Thomas W. [1 ]
Fickes, Michael G. [1 ]
Bhagavatula, Lakshmi [1 ]
McDermott, Todd [1 ]
Wittenberger, Steven [1 ]
Richards, Steven J. [1 ]
Longenecker, Kenton L. [1 ]
Stewart, Kent D. [1 ]
机构
[1] Abbott Labs, Metab Dis Res, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA
关键词
D O I
10.1021/jm060777o
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Dipeptidyl peptidase-IV (DPP-IV) inhibitors are poised to be the next major drug class for the treatment of type 2 diabetes. Structure-activity studies of substitutions at the C5 position of the 2-cyanopyrrolidide warhead led to the discovery of potent inhibitors of DPP-IV that lack activity against DPP8 and DPP9. Further modification led to an extremely potent (Ki(DPP-IV)) 1.0 nM) and selective (Ki(DPP8) > 30 mu M; Ki(DPP9) > 30 mu M) clinical candidate, ABT-279, that is orally available, efficacious, and remarkably safe in preclinical safety studies.
引用
收藏
页码:6416 / 6420
页数:5
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