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- [23] Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal TumorsJOURNAL OF MEDICINAL CHEMISTRY, 2018, 61 (19) : 8797 - 8810Kettle, Jason G.Anjum, RanaBarry, EvanBhavsar, DeepaBrown, CrystalBoyd, ScottCampbell, AndrewGoldberg, KristinGrondine, MichaelGuichard, SylvieHardy, Christopher J.Hunt, TomJones, Rhys D. O.Li, XiuweiMoleva, OlgaOgg, DerekOverman, Ross C.Packer, Martin J.Pearson, StuartSchimpl, MarianneShao, WenlinSmith, AaronSmith, James M.Stead, DarrenStokes, SteveTucker, MichaelYe, Yang
- [24] Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for AsthmaJOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (17) : 7769 - 7787af Rosenschold, Magnus MunckJohannesson, PetraNikitidis, AntoniosTyrchan, ChristianChang, Hui-FangRonn, RobertChapman, DaveUllah, VictoriaNikitidis, GrigoriosGlader, PernillaKack, HelenaBonn, BrittaWagberg, FredrikBjorkstrand, EvaAndersson, UlfSwedin, LindaRohman, MattiasAndreasson, TheresaBergstrom, Eva LammJiang, FanyiZhou, Xiao-HongLundqvist, Anders J.Malmberg, AnnaEk, MargaretaGordon, EuanPettersen, AnnaRipa, LenaDavis, Andrew M.
- [25] A Potent, Selective, and Orally Bioavailable HCV NS5A Inhibitor for Treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazol-2-yl)pyrrolidine-2-carboxamideJOURNAL OF MEDICINAL CHEMISTRY, 2017, 60 (01) : 228 - 247Kang, Iou-JiunHsu, Sheng-JuYang, Hui-YunYeh, Teng-KuanLee, Chung-ChiLee, Yen-ChunTian, Ya-WenSong, Jen-ShinHsu, Tsu-AnChao, Yu-ShengYueh, AndrewChern, Jyh-Haur
- [26] Discovery of methyl 3-((2-((1-(dimethylglycyl)-5-methoxyindolin-6-yl)amino)-5-(trifluoro-methyl) pyrimidin-4-yl)amino)thiophene-2-carboxylate as a potent and selective polo-like kinase 1 (PLK1) inhibitor for combating hepatocellular carcinomaEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 206Deng, ZhouChen, GuyueLiu, ShuangLi, YunzhanZhong, JiajiZhang, BaodingLi, LiHuang, HuiyingWang, ZhengXu, QingyanDeng, Xianming
- [27] Exploring the role of bromine at C(10) of (+)-4-[2-[4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide (Sch-66336):: The discovery of indolocycloheptapyridine inhibitors of farnesyl protein transferaseJOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (18) : 3854 - 3864Taveras, AGAki, CChao, JPDoll, RJLalwani, TGirijavallabhan, VStrickland, CLWindsor, WTWeber, PHollinger, FSnow, MPatton, RKirschmeier, PJames, LLiu, MNomeir, A
- [28] Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical DevelopmentJOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (12) : 5650 - 5660Blake, James F.Burkard, MichaelChan, JocelynChen, HuifenChou, Kang-JyeDiaz, DoloresDudley, Danette A.Gaudino, John J.Gould, Stephen E.Grina, JonasHunsaker, ThomasLiu, LichuanMartinson, MatthewMoreno, DavidMueller, LarsOrr, ChristinePacheco, PatriciaQin, AnnRasor, KevinRen, LiRobarse, KirkShahidi-Latham, SheerinStults, JeffreySullivan, FrancisWang, WeiruYin, JianpingZhou, AiheBelvin, MarciaMerchant, MarkMoffat, JohnSchwarz, Jacob B.
- [29] Discovery of (R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4-b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological MalignanciesJOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (03) : 1523 - 1540Wang, Hui-LingAndrews, Kristin L.Booker, Shon K.Canon, JudeCee, Victor J.Chavez, Frank, Jr.Chen, YupingEastwood, HeatherGuerrero, NadiaHerberich, BradHickman, DeanLanman, Brian A.Laszlo, Jimmy, IIILee, Matthew R.Lipford, J. RussellMattson, BethanyMohr, ChristopherYen NguyenNorman, Mark H.Pettus, Liping H.Powers, DavidReed, Anthony B.Rex, KarenSastri, ChristineTamayo, NuriaWang, PaulWinston, Jeffrey T.Wu, BinWu, QiongWu, TianWurz, Ryan P.Xu, YangZhou, YihongTasker, Andrew S.
- [30] The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor AgentJOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (01) : 147 - 169Sampson, Peter B.Liu, YongForrest, BryanCumming, GrahamLi, Sze-WanPatel, Narendra KumarEdwards, LouiseLaufer, RadoslawFeher, MiklosBan, FuqiangAwrey, Donald E.Mao, GuodongPlotnikova, OlgaHodgson, RichardBeletskaya, IrinaMason, Jacqueline M.Luo, XunyiNadeem, VincentWei, XinKiarash, RezaMadeira, BrianHuang, PingMak, Tak W.Pan, GuohuaPauls, Henry W.