TMSCl-Mediated catalytic carbocupration of alkynoates: An unprecedented and remarkable effect of catalyst loading on highly selective stereochemical induction via a TMS-allenoate intermediate

被引：19

作者：

Jennings, MP ^{[1
]}

Sawant, KB ^{[1
]}

机构：

[1] Univ Alabama, Dept Chem, Tuscaloosa, AL 35487 USA

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 2004卷 / 15期

关键词：

carbocupration; cuprates; grignard reaction; propiolates; TMS-allenoate;

D O I：

10.1002/ejoc.200400314

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The TMSCl-mediated catalytic carbocupration of alkynoates has been investigated. It has been shown that catalyst loadings as low as 30 mol% readily allow for high yields and diastereoselectivities for a series of Grignard reagents. In addition, an unprecedented and remarkable effect of catalyst loading on stereochemical induction has been observed. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

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收藏

页码：3201 / 3204

页数：4

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