Clinical value of interferon-γ release assay in the diagnosis of active tuberculosis

被引:19
作者
Ai, Lu [1 ]
Feng, Pinning [1 ]
Chen, Dubo [1 ]
Chen, Shaoqian [1 ]
Xu, Hongxu [1 ]
机构
[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Clin Lab, 52 Zhongshan Second Rd, Guangzhou 510080, Guangdong, Peoples R China
关键词
tuberculosis; early diagnosis; LATENT;
D O I
10.3892/etm.2019.7696
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Sensitivity and specificity of the interferon-gamma release test for active tuberculosis screening were evaluated. Due to the high-test cost of imported IGRAs, QFT-GIT and T-SPOT.TB, we applied a cheaper domestic TB-IGRA which was approved in China recently. We recruited 740 patients and performed tuberculosis interferon release test (IGRAs), detection of Mycobacterium tuberculosis IgG antibody (TB-IgG) and tuberculin skin test (TST). The sensitivity of the three methods are 90.8, 40.0 and 75.45%, with specificity of 76.62, 74.47 and 72.27%. The area under the ROC curve according to the value of T-N detected by IGRAs was 0.878 (95% CI, 0.839-0.917), with the area under the curve for the diagnosis of active pulmonary tuberculosis and extrapulmonary tuberculosis being 0.839 and 0.841 respectively. The interferon-gamma release test seems to be superior to TST and TB-IgG as a screening tool for the detection of active tuberculosis in China.
引用
收藏
页码:1253 / 1257
页数:5
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