The elevated lipoprotein-associated phospholipase A2 activity is associated with the occurrence and recurrence of acute cerebral infarction

被引：108

作者：

Wei, Lingli ^{[1
]}

Ke, Zunyu ^{[2
]}

Zhao, Yu ^{[3
]}

Cai, Zhiyou ^{[4
]}

机构：

[1] Hubei Univ Arts & Sci, Xiangyang Cent Hosp, Dept Neurol, Affiliated Hosp, Xiangyang, Peoples R China

[2] Hubei Univ Med, Renmin Hosp, Dept Neurol, Shiyan, Hubei Province, Peoples R China

[3] Harbin Med Univ, Dept Neurol, Affiliated Hosp 4, Harbin, Heilongjiang Pr, Peoples R China

[4] Chongqing Gen Hosp, Dept Neurol, 312 Zhongshan First Rd, Chongqing 400013, Chongqing Munic, Peoples R China

来源：

NEUROREPORT | 2017年 / 28卷 / 06期

关键词：

atherosclerosis; ischemic stroke; risk factor; stroke subtype; C-REACTIVE PROTEIN; INCIDENT ISCHEMIC-STROKE; CORONARY-HEART-DISEASE; ATHEROSCLEROSIS RISK; VESSEL OCCLUSION; COMMUNITIES; WOMEN; TIA; PREDICTION; PLASMA;

D O I：

10.1097/WNR.0000000000000765

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

There is a strong association between lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) levels and atherosclerosis-related diseases. The aim of this study was to investigate the role of Lp-PLA(2) in the ischemic stroke and further offer clinical evidence that measuring Lp-PLA(2) helps predict the risk of stroke occurrence and recurrence. A total of 328 hospitalized patients were recruited, including 179 cases of acute cerebral infarction (ACI) and 149 non-ACI controls. The serum level of Lp-PLA(2) in ACI was significantly higher than non-ACI. The serum level of Lp-PLA(2) in the recurrence of ACI was significantly higher than the nonrecurrence. The serum levels of Lp-PLA(2) in large-artery atherosclerosis subtype were the highest among the subtypes of the Trial of Org 10172 in Acute Stroke Treatment and non-ACI controls. The level of Lp-PLA(2) in large-artery atherosclerosis and the cardioembolism group was statistically significantly higher than that of the control cases. There was no statistically significant difference between the small-vessel occlusion group and the control cases. The present study confirmed that the elevated Lp-PLA(2) level can be a risk factor for ischemic stroke in the Chinese population. The serum level of Lp-PLA(2) may be a predictive factor for the recurrence of ACI.

引用

页码：325 / 330

页数：6

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