Could basement membrane alterations, resembling micro-wounds at the dermo-epidermal junction in psoriatic non-lesional skin, make the skin susceptible to lesion formation?

被引:8
作者
Bozo, Renata [1 ,2 ]
Flink, Lili Borbala [1 ]
Belso, Nora [1 ,2 ]
Guban, Barbara [1 ]
Szell, Marta [3 ,4 ]
Kemeny, Lajos [1 ,2 ,3 ]
Bata-Csorgo, Zsuzsanna [1 ,2 ,3 ]
机构
[1] Univ Szeged, Dept Dermatol & Allergol, Koranyi Fasor 6, H-6720 Szeged, Hungary
[2] HCEMM SZTE Skin Res Grp, Szeged, Hungary
[3] MTA SZTE Dermatol Res Grp, Szeged, Hungary
[4] Univ Szeged, Dept Med Genet, Szeged, Hungary
基金
欧盟地平线“2020”; 匈牙利科学研究基金会;
关键词
basement membrane; dermal-epidermal junction; non-lesional skin; psoriasis; wound healing; OLIGOMERIC MATRIX PROTEIN; KERATINOCYTE GROWTH-FACTOR; DELTA T-CELLS; NONCODING RNA; FIBRONECTIN; EXPRESSION; PROLIFERATION; METALLOPROTEINASES; DIFFERENTIATION; PATHOGENESIS;
D O I
10.1111/exd.14267
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Current data suggest that tissue microenvironment control immune functions. Therefore, understanding the tissue environment in which immune activation occurs will enhance our capability to interfere with abnormal immune pathology. Here, we argue that studying the constitutively abnormal functions of clinically uninvolved psoriatic skin in patients with plaque type psoriasis is very important to better understand psoriasis pathobiology, because non-lesional skin provides the tissue environment in which the psoriatic lesion develops. A key question in psoriasis is what initiates the abnormal, uncontrolled immune activation in the first place and the answer may lie in the skin. In light of this concept, we summarize abnormalities at the dermal-epidermal junction region which shows a special "non-healing-like" micro-wound phenotype in the psoriatic non-lesional skin that may act as a crucial susceptibility factor in the development of the disease.
引用
收藏
页码:765 / 772
页数:8
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