Synthesis and insecticidal activity of novel hydrazone compounds derived from a naturally occurring lignan podophyllotoxin against Mythimna separata (Walker)

被引：25

作者：

Wang, Yi ^{[1
,2
]}

Yu, Xiang ^{[1
]}

Zhi, Xiaoyan ^{[1
]}

Xiao, Xiao ^{[1
]}

Yang, Chun ^{[1
]}

Xu, Hui ^{[1
]}

机构：

[1] Northwest A&F Univ, Coll Sci, Lab Pharmaceut Design & Synth, Yangling 712100, Shaanxi Provinc, Peoples R China

[2] Shanxi Agr Univ, Coll Agr, Taigu 030801, Shanxi Province, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Podophyllotoxin; Insecticidal activity; Botanical insecticide; Structural modification; Mythimna separata Walker; ACTIVITY-RELATIONSHIP QSAR; BIOLOGICAL-ACTIVITIES; ANTIFUNGAL ACTIVITY; DERIVATIVES; SEMISYNTHESIS; BIOSYNTHESIS; COMPONENTS; MODE;

D O I：

10.1016/j.bmcl.2014.04.074

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In continuation of our program aimed at the discovery and development of natural-product-based insecticidal agents, a series of novel hydrazone derivatives of podophyllotoxin, which is a naturally occurring aryltetralin lignan and isolated as the main secondary metabolite from the roots and rhizomes of Podophyllum species, were synthesized and evaluated as insecticidal agents against the pre-third-instar larvae of oriental armyworm, Mythimna separata (Walker) in vivo at 1 mg/mL. Especially compounds 8i, 8j, 8t, and 8u showed the more potent insecticidal activity with the final mortality rates greater than 60%. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：2621 / 2624

页数：4

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