Dominant behaviours in the expression of human carbonic anhydrase hCA I activity

被引：14

作者：

Abdelrahim, M. Yahia M. ^{[1
]}

Tanc, Muhammet ^{[2
]}

Winum, Jean-Yves ^{[3
]}

Supuran, Claudiu T. ^{[3
]}

Barboiu, Mihail ^{[1
]}

机构：

[1] ENSCM UMII UMR CNRS 5635, Inst Europeen Membranes, Adaptat Supramol Nanosyst Grp, F-34095 Montpellier 5, France

[2] Univ Florence, Lab Chim Bioinorgan, I-50019 Florence, Italy

[3] Ecole Natl Super Chim Montpellier, CNRS, UMR 5247, IBMM, F-34296 Montpellier, France

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 59期

关键词：

DYNAMIC COMBINATORIAL CHEMISTRY; DRUG DISCOVERY; ISOZYMES I; NEURAMINIDASE INHIBITORS; SUPRAMOLECULAR CHEMISTRY; LIBRARIES; ACTIVATORS; SELECTION; SITE; DERIVATIVES;

D O I：

10.1039/c4cc03289f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we describe the screening via Dynamic Deconvolution of DCLs of inhibitors (CAIs) and activators (CAAs) of hCA I. The inhibitory effects dominate over the activating ones, while the CAAs may be identified in the absence of CAIs.

引用

页码：8043 / 8046

页数：4

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