An atom-economic and odorless thia-Michael addition in a deep eutectic solvent

被引：36
作者：
Azizi, Najmedin [1 ]
Yadollahy, Zahra [1 ]
Rahimzadeh-Oskooee, Amin [1 ]
机构：
[1] Chem & Chem Engn Res Ctr Iran, Tehran, Iran
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 10期
关键词：
Atom economy; Deep eutectic solvent; Green chemistry; Odorless thiol; Thia-Michael addition; S-ALKYLISOTHIOURONIUM SALTS; EPOXIDE RINGS; ENANTIOSELECTIVE AMINOLYSIS; EFFICIENT SYNTHESIS; AROMATIC-AMINES; THIOLYSIS; EQUIVALENTS; SULFIDES; CATALYST; WATER;
D O I：
10.1016/j.tetlet.2014.01.104
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first 100% atom-efficient and odorless protocol for carbon-sulfur bond formation in a deep eutectic solvent (DES) as both the reaction medium and catalyst is reported. The biodegradable and inexpensive DES provides an efficient and convenient ionic reaction medium for the thia-Michael addition with in situ generation of S-alkylisothiouronium salts in place of thiols without the urea by-product segment. This protocol offers several advantages including short reaction times, high yields, clean reactions, and inexpensive and commercially available starting materials. (C) 2014 Elsevier Ltd. All rights reserved.
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页码：1722 / 1725
页数：4
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