Telomeres and telomerase in cancer stem cells

被引：77
作者：
Ju, Zhenyu [1 ]
Rudolph, Karl Lenhard [1 ]
机构：
[1] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-30625 Hannover, Germany
来源：
EUROPEAN JOURNAL OF CANCER | 2006年 / 42卷 / 09期
关键词：
senescence; telomeres; telomerase; DNA-damage; apoptosis; cell cycle arrest; p53; ageing; chromosomal instability; p21;
D O I：
10.1016/j.ejca.2006.01.040
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Alterations in telomere dynamics both suppress and facilitate malignant transformation by regulating genomic stability and cell lifespan. Checkpoints induced by telomere dysfunction play a major role in tumour suppression, whereas telomere shortening contributes to the initiation of cancer by inducing chromosomal instability. Since stem cells are exposed to various tumourigenic agents and stresses throughout their lifetime, the ageing stem cell is a major target of malignant trans formation. This review summarises our knowledge of telomere length and telomerase activity in stem cells during ageing and carcinogenesis. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1197 / 1203
页数：7
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