Telomeres and telomerase in cancer stem cells

被引：77

作者：

Ju, Zhenyu ^{[1
]}

Rudolph, Karl Lenhard ^{[1
]}

机构：

[1] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-30625 Hannover, Germany

来源：

EUROPEAN JOURNAL OF CANCER | 2006年 / 42卷 / 09期

关键词：

senescence; telomeres; telomerase; DNA-damage; apoptosis; cell cycle arrest; p53; ageing; chromosomal instability; p21;

D O I：

10.1016/j.ejca.2006.01.040

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Alterations in telomere dynamics both suppress and facilitate malignant transformation by regulating genomic stability and cell lifespan. Checkpoints induced by telomere dysfunction play a major role in tumour suppression, whereas telomere shortening contributes to the initiation of cancer by inducing chromosomal instability. Since stem cells are exposed to various tumourigenic agents and stresses throughout their lifetime, the ageing stem cell is a major target of malignant trans formation. This review summarises our knowledge of telomere length and telomerase activity in stem cells during ageing and carcinogenesis. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1197 / 1203

页数：7

共 75 条

[1] Self-renewal and solid tumor stem cells [J].

Al-Hajj, M ;

Clarke, MF .

ONCOGENE, 2004, 23 (43) :7274-7282

[2] ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage [J].

Aladjem, MI ;

Spike, BT ;

Rodewald, LW ;

Hope, TJ ;

Klemm, M ;

Jaenisch, R ;

Wahl, GM .

CURRENT BIOLOGY, 1998, 8 (03) :145-155

[3] High telomerase activity in primary lung cancers: Association with increased cell proliferation rates and advanced pathologic stage [J].

Albanell, J ;

Lonardo, F ;

Rusch, V ;

Engelhardt, M ;

Langenfeld, J ;

Han, W ;

Klimstra, D ;

Venkatraman, E ;

Moore, MAS ;

Dmitrovsky, E .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1997, 89 (21) :1609-1615

[4] TELOMERE SHORTENING IS ASSOCIATED WITH CELL-DIVISION IN-VITRO AND IN-VIVO [J].

ALLSOPP, RC ;

CHANG, E ;

KASHEFIAAZAM, M ;

ROGAEV, EI ;

PIATYSZEK, MA ;

SHAY, JW ;

HARLEY, CB .

EXPERIMENTAL CELL RESEARCH, 1995, 220 (01) :194-200

[5] TELOMERE LENGTH PREDICTS REPLICATIVE CAPACITY OF HUMAN FIBROBLASTS [J].

ALLSOPP, RC ;

VAZIRI, H ;

PATTERSON, C ;

GOLDSTEIN, S ;

YOUNGLAI, EV ;

FUTCHER, AB ;

GREIDER, CW ;

HARLEY, CB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) :10114-10118

[6] EVIDENCE FOR A CRITICAL TELOMERE LENGTH IN SENESCENT HUMAN FIBROBLASTS [J].

ALLSOPP, RC ;

HARLEY, CB .

EXPERIMENTAL CELL RESEARCH, 1995, 219 (01) :130-136

[7] Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice [J].

Artandi, SE ;

Chang, S ;

Lee, SL ;

Alson, S ;

Gottlieb, GJ ;

Chin, L ;

DePinho, RA .

NATURE, 2000, 406 (6796) :641-645

[8] Constitutive telomerase expression promotes mammary carcinomas in aging mice [J].

Artandi, SE ;

Alson, S ;

Tietze, MK ;

Sharpless, NE ;

Ye, S ;

Greenberg, RA ;

Castrillon, DH ;

Horner, JW ;

Weiler, SR ;

Carrasco, RD ;

DePinho, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (12) :8191-8196

[9] DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis [J].

Bartkova, J ;

Horejsi, Z ;

Koed, K ;

Krämer, A ;

Tort, F ;

Zieger, K ;

Guldberg, P ;

Sehested, M ;

Nesland, JM ;

Lukas, C ;

Orntoft, T ;

Lukas, J ;

Bartek, J .

NATURE, 2005, 434 (7035) :864-870

[10] Switching and signaling at the telomere [J].

Blackburn, EH .

CELL, 2001, 106 (06) :661-673

← 1 2 3 4 5 6 7 8 →