Compressive Strength and Bioactivity Properties of Photopolymerizable Hybrid Composite Hydrogels for Bone Tissue Engineering

被引：23
作者：
Killion, John A. [1 ]
Geever, Luke M. [1 ]
Devine, Declan M. [1 ,2 ]
Farrell, Hugh [3 ]
Higginbotham, Clement L. [1 ]
机构：
[1] Athlone Inst Technol, Mat Res Inst, Athlone, Westmeath, Ireland
[2] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Ctr Adv Orthopaed Studies, Boston, MA 02215 USA
[3] Athlone Inst Technol, BioSci Res Inst, Athlone, Westmeath, Ireland
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2014年 / 63卷 / 13期
关键词：
drug release; beta-tricalcium phosphate; Antimicrobials; biomineralization; mechanical properties; hydrogels; MECHANICAL-PROPERTIES; IN-VITRO; POROUS SCAFFOLDS; GLYCOL HYDROGELS; REGENERATION; NANOPARTICLES; FABRICATION; GENTAMICIN;
D O I：
10.1080/00914037.2013.854238
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
The drug release capabilities of synthetic bone scaffolds have often been overlooked. In this study novel poly(ethylene) glycol and beta-tricalcium phosphate hydrogel composites were photopolymerized and evaluated in terms of mechanical strength, bioactivity, antimicrobial release profile, and the efficacy of released antimicrobials. Young's modulus values ranged between 4.36 and 8.70MPa. This increase was associated with the physical bonding interaction between polymer and bioceramic. Bioactivity was confirmed by the formation of globular crystals. Drug release studies showed the diffusion of vancomycin from hydrogel composites can be controlled by the hydrogels' three-dimensional structure. Moreover, vancomycin loaded samples showed activity against Staphylococcus aureus.
引用
收藏
页码：641 / 650
页数：10
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