Highly efficient one-pot, three-component synthesis of 1,5-benzodiazepine derivatives

被引：14
作者：
Li, Xiao-Qing [1 ]
Wang, Lan-Zhi [1 ]
机构：
[1] Hebei Normal Univ, Coll Chem & Mat Sci, Shijiazhuang 050024, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2014年 / 25卷 / 02期
基金：
中国国家自然科学基金;
关键词：
One-pot; Synthesis; 1,5-Benzodiazepine derivative; ANTICONVULSANT AGENTS; BENZODIAZEPINES; 4-COMPONENT; CATALYST;
D O I：
10.1016/j.cclet.2013.11.035
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A general, mild and efficient protocol for the synthesis of ethyl 4-methy1-2-(thiophen)-2,5-dihydro-1,5-benzodiazepine-3-carboxylate is achieved for first time using H3PMo12O40 in ethanol at 0 degrees C by a one-pot, three-component condensation of various thiophene aldehydes, substituted o-phenylenediamines and ethyl acetoacetate. Compared with the conventional synthesis method, this procedure has the advantages of convenient operation, excellent yields, and environmentally benign. A plausible formation mechanism has been proposed. The structure of the products is characterized by H-1 NMR, IR, MS and elemental analysis. (C) 2013 Lan-Zhi Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：327 / 332
页数：6
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