共 39 条
Immune Signature of Enhanced Functional Avidity CD8+ T Cells in vivo Induced by Vaccinia Vectored Vaccine
被引:9
作者:

Hu, Zhidong
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China

Zhu, Lingyan
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China

Wang, Jing
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China

Wan, Yanmin
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China

Yuan, Songhua
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China

Chen, Jian
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China

Ding, Xiangqing
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China

Qiu, Chenli
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China

Zhang, Xiaoyan
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China
Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China
Fudan Univ, Key Lab Med Mol Virol MOE MOH, Shanghai, Peoples R China Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China

Qiu, Chao
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China
Fudan Univ, Key Lab Med Mol Virol MOE MOH, Shanghai, Peoples R China Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China

Xu, Jianqing
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China
Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China
Fudan Univ, Key Lab Med Mol Virol MOE MOH, Shanghai, Peoples R China Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China
机构:
[1] Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China
[2] Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China
[3] Fudan Univ, Key Lab Med Mol Virol MOE MOH, Shanghai, Peoples R China
来源:
基金:
中国国家自然科学基金;
关键词:
TOLL-LIKE RECEPTOR;
ANTIGEN SENSITIVITY;
POLYFUNCTIONALITY;
PROGRESSION;
EXPRESSION;
EPITOPES;
PROTEIN;
D O I:
10.1038/srep41558
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
Functional avidity of T cells is a critical determinant for clearing viral infection and eliminating tumor. Understanding how functional avidity is maintained in T cells is imperative for immunotherapy. However, studies systematically characterize T cell with high functional avidity induced in vivo are still lacking. Previously, we and others found vaccinia vectored vaccine (VACV) induced antigen-specific CD8(+) T cells with relatively high functional avidity to those from DNA vaccine. Herein, we used functional, immune phenotyping and transcriptomic studies to define the immune signature of these CD8(+) T cells with high functional avidity. Antigen-specific CD8(+) T cells induced by VACV executed superior in vivo killing activity and displayed a distinct transcriptional profile, whereas no significantly differences were found in composition of memory sub-populations and cytokine poly-functionality. Transcriptional analyses revealed unique features of VACV induced CD8(+) T cells in several biological processes, including transport, cell cycle, cell communication and metabolic processes. In summary, we characterize CD8(+) T cells of high functional avidity induced in vivo by VACV, which not only improves our understanding of adaptive T cell immunity in VACV vaccination, but also provides clues to modulate functional avidity of CD8(+) T cells for T cell based immunotherapy.
引用
收藏
页数:12
相关论文
共 39 条
[1]
High-avidity CD8+ T cells -: Optimal soldiers in the war against viruses and tumors
[J].
Alexander-Miller, MA
.
IMMUNOLOGIC RESEARCH,
2005, 31 (01)
:13-24

Alexander-Miller, MA
论文数: 0 引用数: 0
h-index: 0
机构:
Wake Forest Univ, Sch Med, Dept Microbiol & Immunol, Winston Salem, NC 27157 USA Wake Forest Univ, Sch Med, Dept Microbiol & Immunol, Winston Salem, NC 27157 USA
[2]
Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover
[J].
Almeida, Jorge R.
;
Price, David A.
;
Papagno, Laura
;
Arkoub, Zaina Ait
;
Sauce, Delphine
;
Bornstein, Ethan
;
Asher, Tedi E.
;
Samri, Assia
;
Schnuriger, Aurelie
;
Theodorou, Ioannis
;
Costagliola, Dominique
;
Rouzioux, Christine
;
Agut, Henri
;
Marcelin, Anne-Genevieve
;
Douek, Daniel
;
Autran, Brigitte
;
Appay, Victor
.
JOURNAL OF EXPERIMENTAL MEDICINE,
2007, 204 (10)
:2473-2485

Almeida, Jorge R.
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Price, David A.
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Papagno, Laura
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Arkoub, Zaina Ait
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Sauce, Delphine
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Bornstein, Ethan
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Asher, Tedi E.
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Samri, Assia
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Schnuriger, Aurelie
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Theodorou, Ioannis
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

论文数: 引用数:
h-index:
机构:

Rouzioux, Christine
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Agut, Henri
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Marcelin, Anne-Genevieve
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Douek, Daniel
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Autran, Brigitte
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France

Appay, Victor
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France INSERM, Cellular Immunol Lab, U543, Avenir Grp, F-75654 Paris 13, France
[3]
Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity
[J].
Almeida, Jorge R.
;
Sauce, Delphine
;
Price, David A.
;
Papagno, Laura
;
Shin, So Youn
;
Moris, Arnaud
;
Larsen, Martin
;
Pancino, Gianfranco
;
Douek, Daniel C.
;
Autran, Brigitte
;
Saez-Cirion, Asier
;
Appay, Victor
.
BLOOD,
2009, 113 (25)
:6351-6360

Almeida, Jorge R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 06, Cellular Immunol Lab, Inserm U945, Avenir Grp,Hop Pitie Salpetriere, Paris, France Univ Paris 06, Cellular Immunol Lab, Inserm U945, Avenir Grp,Hop Pitie Salpetriere, Paris, France

Sauce, Delphine
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 06, Cellular Immunol Lab, Inserm U945, Avenir Grp,Hop Pitie Salpetriere, Paris, France Univ Paris 06, Cellular Immunol Lab, Inserm U945, Avenir Grp,Hop Pitie Salpetriere, Paris, France

Price, David A.
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID, Vaccine Res Ctr, Human Immunol Sect, Natl Inst Hlth, Bethesda, MD 20892 USA
Cardiff Univ, Sch Med, Dept Med Biochem & Immunol, Cardiff, Wales Univ Paris 06, Cellular Immunol Lab, Inserm U945, Avenir Grp,Hop Pitie Salpetriere, Paris, France

Papagno, Laura
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 06, Cellular Immunol Lab, Inserm U945, Avenir Grp,Hop Pitie Salpetriere, Paris, France Univ Paris 06, Cellular Immunol Lab, Inserm U945, Avenir Grp,Hop Pitie Salpetriere, Paris, France

Shin, So Youn
论文数: 0 引用数: 0
h-index: 0
机构: Univ Paris 06, Cellular Immunol Lab, Inserm U945, Avenir Grp,Hop Pitie Salpetriere, Paris, France

Moris, Arnaud
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Pasteur, Unite Virus & Immun, Paris, France Univ Paris 06, Cellular Immunol Lab, Inserm U945, Avenir Grp,Hop Pitie Salpetriere, Paris, France

Larsen, Martin
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 06, Cellular Immunol Lab, Inserm U945, Avenir Grp,Hop Pitie Salpetriere, Paris, France Univ Paris 06, Cellular Immunol Lab, Inserm U945, Avenir Grp,Hop Pitie Salpetriere, Paris, France

Pancino, Gianfranco
论文数: 0 引用数: 0
h-index: 0
机构:
Unite Regulat Infect Retrovirales, Paris, France Univ Paris 06, Cellular Immunol Lab, Inserm U945, Avenir Grp,Hop Pitie Salpetriere, Paris, France

Douek, Daniel C.
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID, Vaccine Res Ctr, Human Immunol Sect, Natl Inst Hlth, Bethesda, MD 20892 USA Univ Paris 06, Cellular Immunol Lab, Inserm U945, Avenir Grp,Hop Pitie Salpetriere, Paris, France

Autran, Brigitte
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 06, Cellular Immunol Lab, Inserm U945, Avenir Grp,Hop Pitie Salpetriere, Paris, France Univ Paris 06, Cellular Immunol Lab, Inserm U945, Avenir Grp,Hop Pitie Salpetriere, Paris, France

Saez-Cirion, Asier
论文数: 0 引用数: 0
h-index: 0
机构:
Unite Regulat Infect Retrovirales, Paris, France Univ Paris 06, Cellular Immunol Lab, Inserm U945, Avenir Grp,Hop Pitie Salpetriere, Paris, France

Appay, Victor
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 06, Cellular Immunol Lab, Inserm U945, Avenir Grp,Hop Pitie Salpetriere, Paris, France Univ Paris 06, Cellular Immunol Lab, Inserm U945, Avenir Grp,Hop Pitie Salpetriere, Paris, France
[4]
CD8+ T cell efficacy in vaccination and disease
[J].
Appay, Victor
;
Douek, Daniel C.
;
Price, David A.
.
NATURE MEDICINE,
2008, 14 (06)
:623-628

论文数: 引用数:
h-index:
机构:

Douek, Daniel C.
论文数: 0 引用数: 0
h-index: 0
机构:
US Natl Inst Hlth, Vaccine Res Ctr, Human Immunol Sect, Bethesda, MD 20892 USA Univ Paris 06, Hop Pitie Salpetriere, Ave Grp, Inst Natl Sante & Rech Med U543, F-75013 Paris, France

Price, David A.
论文数: 0 引用数: 0
h-index: 0
机构:
US Natl Inst Hlth, Vaccine Res Ctr, Human Immunol Sect, Bethesda, MD 20892 USA
Cardiff Univ, Sch Med, Dept Med Biochem & Immunol, Cardiff CF14 4XN, Wales Univ Paris 06, Hop Pitie Salpetriere, Ave Grp, Inst Natl Sante & Rech Med U543, F-75013 Paris, France
[5]
Antigen sensitivity and T-cell receptor avidity as critical determinants of HIV control
[J].
Appay, Victor
;
Iglesias, Maria C.
.
CURRENT OPINION IN HIV AND AIDS,
2011, 6 (03)
:157-162

Appay, Victor
论文数: 0 引用数: 0
h-index: 0
机构:
Hop La Pitie Salpetriere, Avenir Grp, INSERM, UMR S 945, Paris, France Hop La Pitie Salpetriere, Avenir Grp, INSERM, UMR S 945, Paris, France

Iglesias, Maria C.
论文数: 0 引用数: 0
h-index: 0
机构:
Hop La Pitie Salpetriere, Avenir Grp, INSERM, UMR S 945, Paris, France Hop La Pitie Salpetriere, Avenir Grp, INSERM, UMR S 945, Paris, France
[6]
Epitope-dependent avidity thresholds for cytotoxic T-lymphocyte clearance of virus-infected cells
[J].
Bennett, Michael S.
;
Ng, Hwee L.
;
Dagarag, Mirabelle
;
Ali, Ayub
;
Yang, Otto O.
.
JOURNAL OF VIROLOGY,
2007, 81 (10)
:4973-4980

Bennett, Michael S.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

Ng, Hwee L.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

Dagarag, Mirabelle
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

Ali, Ayub
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

Yang, Otto O.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
[7]
High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control
[J].
Berger, Christoph T.
;
Frahm, Nicole
;
Price, David A.
;
Mothe, Beatriz
;
Ghebremichael, Musie
;
Hartman, Kari L.
;
Henry, Leah M.
;
Brenchley, Jason M.
;
Ruff, Laura E.
;
Venturi, Vanessa
;
Pereyra, Florencia
;
Sidney, John
;
Sette, Alessandro
;
Douek, Daniel C.
;
Walker, Bruce D.
;
Kaufmann, Daniel E.
;
Brander, Christian
.
JOURNAL OF VIROLOGY,
2011, 85 (18)
:9334-9345

Berger, Christoph T.
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA
Harvard Univ, Boston, MA 02115 USA MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA

Frahm, Nicole
论文数: 0 引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, NIAID HIV Vaccine Trials Network HVTN, Seattle, WA 98104 USA MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA

Price, David A.
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA
Cardiff Univ, Sch Med, Dept Infect Immun & Biochem, Cardiff, S Glam, Wales MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA

Mothe, Beatriz
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Autonoma Badalona, Hosp Germans Trias & Pujol, Lluita Sida Fdn, Barcelona, Spain
Hosp Badalona Germans Trias & Pujol, IrsiCaixa AIDS Res Inst HIVACAT, Barcelona, Spain MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA

论文数: 引用数:
h-index:
机构:

Hartman, Kari L.
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA
Harvard Univ, Boston, MA 02115 USA MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA

Henry, Leah M.
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA
Harvard Univ, Boston, MA 02115 USA MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA

Brenchley, Jason M.
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA

Ruff, Laura E.
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA

Venturi, Vanessa
论文数: 0 引用数: 0
h-index: 0
机构:
Univ New S Wales, Ctr Vasc Res, Computat Biol Grp, Kensington, NSW 2033, Australia MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA

Pereyra, Florencia
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA
Harvard Univ, Boston, MA 02115 USA MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA

Sidney, John
论文数: 0 引用数: 0
h-index: 0
机构:
La Jolla Inst Allergy & Immunol, La Jolla, CA USA MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA

论文数: 引用数:
h-index:
机构:

Douek, Daniel C.
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA

Walker, Bruce D.
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA
Harvard Univ, Boston, MA 02115 USA
Howard Hughes Med Inst, Chevy Chase, MD USA MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA

Kaufmann, Daniel E.
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA
Harvard Univ, Boston, MA 02115 USA MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA

论文数: 引用数:
h-index:
机构:
[8]
Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression
[J].
Buggert, Marcus
;
Norstrom, Melissa M.
;
Salemi, Marco
;
Hecht, Frederick M.
;
Karlsson, Annika C.
.
JOURNAL OF IMMUNOLOGY,
2014, 192 (10)
:4685-4696

Buggert, Marcus
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Inst, Div Clin Microbiol, Dept Lab Med, S-14186 Stockholm, Sweden Karolinska Inst, Div Clin Microbiol, Dept Lab Med, S-14186 Stockholm, Sweden

Norstrom, Melissa M.
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Inst, Div Clin Microbiol, Dept Lab Med, S-14186 Stockholm, Sweden Karolinska Inst, Div Clin Microbiol, Dept Lab Med, S-14186 Stockholm, Sweden

Salemi, Marco
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Florida, Dept Pathol Immunol & Lab Med, Gainesville, FL 32611 USA
Univ Florida, Emerging Pathogens Inst, Gainesville, FL 32611 USA Karolinska Inst, Div Clin Microbiol, Dept Lab Med, S-14186 Stockholm, Sweden

Hecht, Frederick M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, San Francisco Gen Hosp, San Francisco Posit Hlth Program, San Francisco, CA 94110 USA Karolinska Inst, Div Clin Microbiol, Dept Lab Med, S-14186 Stockholm, Sweden

Karlsson, Annika C.
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Inst, Div Clin Microbiol, Dept Lab Med, S-14186 Stockholm, Sweden Karolinska Inst, Div Clin Microbiol, Dept Lab Med, S-14186 Stockholm, Sweden
[9]
Direct Toll-Like Receptor 8 signaling increases the functional avidity of human CD8+ T lymphocytes generated for adoptive T cell therapy strategies
[J].
Chatillon, Jean-Francois
;
Hamieh, Mohamad
;
Bayeux, Florence
;
Abasq, Claire
;
Fauquembergue, Emilie
;
Drouet, Aurelie
;
Guisier, Florian
;
Latouche, Jean-Baptiste
;
Musette, Philippe
.
IMMUNITY INFLAMMATION AND DISEASE,
2015, 3 (01)
:1-13

Chatillon, Jean-Francois
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rouen, Rouen, France
INSERM, U905, 22 Blvd Gambetta, F-76183 Rouen, France Univ Rouen, Rouen, France

Hamieh, Mohamad
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rouen, Rouen, France
INSERM, U1079, Rouen, France Univ Rouen, Rouen, France

Bayeux, Florence
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U905, 22 Blvd Gambetta, F-76183 Rouen, France Univ Rouen, Rouen, France

Abasq, Claire
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rouen, Rouen, France
INSERM, U905, 22 Blvd Gambetta, F-76183 Rouen, France
Rouen Univ Hosp, Rouen, France Univ Rouen, Rouen, France

Fauquembergue, Emilie
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rouen, Rouen, France
INSERM, U1079, Rouen, France Univ Rouen, Rouen, France

Drouet, Aurelie
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U1079, Rouen, France Univ Rouen, Rouen, France

Guisier, Florian
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rouen, Rouen, France
INSERM, U905, 22 Blvd Gambetta, F-76183 Rouen, France
Rouen Univ Hosp, Rouen, France Univ Rouen, Rouen, France

论文数: 引用数:
h-index:
机构:

Musette, Philippe
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rouen, Rouen, France
INSERM, U905, 22 Blvd Gambetta, F-76183 Rouen, France
Rouen Univ Hosp, Rouen, France Univ Rouen, Rouen, France
[10]
Regulation and function of mTOR signalling in T cell fate decisions
[J].
Chi, Hongbo
.
NATURE REVIEWS IMMUNOLOGY,
2012, 12 (05)
:325-338

Chi, Hongbo
论文数: 0 引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA