Human Papillomavirus Prevalence and Genotype Distribution among HIV-Infected Women in Korea

被引:11
作者
Park, Eun Kyoung [1 ]
Cho, Heerim [1 ]
Lee, Sun Hee [1 ]
Lee, Seung Geun [1 ]
Lee, Sang Yeup [2 ]
Kim, Ki Hyung [3 ]
Lee, Chang Hun [4 ]
Chung, Joo Seop [1 ]
Kwak, Ihm Soo [1 ]
机构
[1] Pusan Natl Univ, Pusan Natl Univ Hosp, Sch Med, Dept Internal Med,Med Res Inst, Pusan, South Korea
[2] Yangsan Pusan Natl Univ Hosp, Dept Family Med, Yangsan, South Korea
[3] Pusan Natl Univ Hosp, Dept Obstet & Gynecol, Pusan 602739, South Korea
[4] Pusan Natl Univ Hosp, Dept Pathol, Pusan 602739, South Korea
关键词
HIV; Women; Human Papillomavirus; Prevalence; Genotype; SQUAMOUS INTRAEPITHELIAL LESIONS; INVASIVE CERVICAL-CANCER; UNIVERSITY-STUDENTS; INCREASED RISK; FEMALE; BUSAN; EPIDEMIOLOGY; POPULATION; VACCINE;
D O I
10.3346/jkms.2014.29.1.32
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The epidemiology on human papillomavirus (HPV) among human immunodeficiency virus (HIV)-infected women in Korea is not well established. A retrospective study was conducted to determine the prevalence and genotype distribution of HPV infection among HIV-infected women in Korea. HPV DNA genotype and cervical cytology were examined in 60 HIV-positive women and 1,938 HIV-negative women. HPV genotypes were analyzed by using a HPV DNA chip. HIV-infected women had higher prevalence of high-risk HPV (hr-HPV) infection (30% vs 4.9%, adjusted odds ratio [AOR], 6.96; 95% confidence interval [CI], 3.63-13.34, P < 0.001) and abnormal cervical cytology (18.3% vs 1.8%, AOR, 10.94; 95% CI, 5.18-23.1, P < 0.001) compared with controls. The most common hr-HPV genotype detected in HIV-infected women was HPV 16 (10%), followed by 18 (6.7%) and 52 (5%). Prevalence of quadrivalent vaccine-preventable types (HPV 6, 11, 16, and 18) was 21.7% and 2.3% in HIV-positive women and HIV-negative women, respectively. Age was a significant risk factor for hr-HPV infection in HIV-infected women (P = 0.039). The presence of hr-HPV was significantly associated with abnormal cervical cytology (P < 0.001). These findings suggest that HPV testing for cervical cancer screening in HIV-infected women would be necessary, particularly among young age group.
引用
收藏
页码:32 / 37
页数:6
相关论文
共 31 条
[1]   Invasive Cervical Cancer Risk Among HIV-Infected Women: A North American Multicohort Collaboration Prospective Study [J].
Abraham, Alison G. ;
D'Souza, Gypsyamber ;
Jing, Yuezhou ;
Gange, Stephen J. ;
Sterling, Timothy R. ;
Silverberg, Michael J. ;
Saag, Michael S. ;
Rourke, Sean B. ;
Rachlis, Anita ;
Napravnik, Sonia ;
Moore, Richard D. ;
Klein, Marina B. ;
Kitahata, Mari M. ;
Kirk, Gregory D. ;
Hogg, Robert S. ;
Hessol, Nancy A. ;
Goedert, James J. ;
Gill, M. John ;
Gebo, Kelly A. ;
Eron, Joseph J. ;
Engels, Eric A. ;
Dubrow, Robert ;
Crane, Heidi M. ;
Brooks, John T. ;
Bosch, Ronald J. ;
Strickler, Howard D. .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2013, 62 (04) :405-413
[2]  
[Anonymous], 1992, MMWR Recomm Rep, V41, P1
[3]  
Bridges CB, 2013, MMWR-MORBID MORTAL W, V62, P9
[4]   Late presentation of HIV disease and its associated factors among newly diagnosed patients before and after abolition of a government policy of mass mandatory screening [J].
Choe, Pyoeng Gyun ;
Park, Wan Beom ;
Song, Jin Su ;
Kim, Nak-Hyun ;
Park, Jin Yong ;
Song, Kyoung-Ho ;
Park, Sang Won ;
Kim, Hong Bin ;
Kim, Nam Joong ;
Oh, Myoung-don .
JOURNAL OF INFECTION, 2011, 63 (01) :60-65
[5]   Serologic response to oncogenic human papillomavirus types in male and female university students in Busan, South Korea [J].
Clifford, Gary M. ;
Shin, Hai-Rim ;
Oh, Jin-Kyoung ;
Waterboer, Tim ;
Ju, Young-Hee ;
Vaccarella, Salvatore ;
Quint, Wim ;
Pawlita, Michael ;
Franceschi, Silvia .
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2007, 16 (09) :1874-1879
[6]   Human Papillomavirus Prevalence and Type Distribution in 3603 HIV-Positive and HIV-Negative Women in the General Population of Tanzania: The PROTECT Study [J].
Dartell, Myassa ;
Rasch, Vibeke ;
Kahesa, Crispin ;
Mwaiselage, Julius ;
Ngoma, Twalib ;
Junge, Jette ;
Gernow, Anne ;
Ejlersen, Sussie Funch ;
Munk, Christian ;
Iftner, Thomas ;
Kjaer, Susanne Kruger .
SEXUALLY TRANSMITTED DISEASES, 2012, 39 (03) :201-208
[7]  
Dols Joke A M, 2012, ISRN Obstet Gynecol, V2012, P514146, DOI 10.5402/2012/514146
[8]   Incidence of cervical squamous intraepithelial lesions in HIV-infected women [J].
Ellerbrock, TV ;
Chiasson, MA ;
Bush, TJ ;
Sun, XW ;
Sawo, D ;
Brudney, K ;
Wright, TC .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (08) :1031-1037
[9]   Human papillomavirus types in 115,789 HPV-positive women: A meta-analysis from cervical infection to cancer [J].
Guan, Peng ;
Howell-Jones, Rebecca ;
Li, Ni ;
Bruni, Laia ;
de Sanjose, Silvia ;
Franceschi, Silvia ;
Clifford, Gary M. .
INTERNATIONAL JOURNAL OF CANCER, 2012, 131 (10) :2349-2359
[10]   Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDH-ANRS CO4): a prospective cohort study [J].
Guiguet, Marguerite ;
Boue, Francois ;
Cadranel, Jacques ;
Lang, Jean-Marie ;
Rosenthal, Eric ;
Costagliola, Dominique .
LANCET ONCOLOGY, 2009, 10 (12) :1152-1159