Diastereoselective conjugate addition of cyanide to α,β-unsaturated oxazolidinones:: Enantioselective synthesis of ent-pregabalin and baclofen

被引：32

作者：

Armstrong, Alan ^{[1
]}

Convine, Nicola J.

Popkin, Matthew E.

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[2] GSK Tonbridge, Tonbridge TN11 9AN, Kent, England

来源：

SYNLETT | 2006年 / 10期

关键词：

conjugate addition; cyanide; samarium; oxazolidinone;

D O I：

10.1055/s-2006-941584

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Conjugate addition of cyanide to chiral alpha, beta-unsaturated oxazolidinones catalyzed by samarium(III) isopropoxide proceeds with good diastereoselectivity. The addition products can be converted into the biologically active targets ent-pregabalin and baclofen.

引用

页码：1589 / 1591

页数：3

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