SYNTHESIS AND BIOLOGICAL EVALUATION OF 4-(4-(DI-(1H-INDOL-3-YL) METHYL) PHENOXY)-2-CHLOROQUINOLINES

被引：0

作者：

Rajesh, K. ^{[1
]}

Reddy, B. Palakshi ^{[1
]}

Vijayakumar, M. ^{[1
]}

机构：

[1] VIT Univ, Div Organ Chem, Sch Sci & Humanities, Vellore 632014, Tamil Nadu, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2009年 / 19卷 / 01期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of various substituted 2,4-dichloroquinolines with 3-[1H-indol-3-yl (4-hydroxyphenyl) methyl]-1H-indole has been carried out leading to novel 4-(4-(di(1H-indol-3-yl) methyl) phenoxy)-2-chloroquinolines with high regioselectivity. All the synthesized compounds were characterized through spectral data and preliminarily evaluated for their in vitro antibacterial activity against various Gram-positive and Gram-negative organisms.

引用

页码：95 / 96

页数：2

共 5 条

[1] Potential antineoplastics. Synthesis and cytotoxicity of certain 4-chloro-3-(2-chloroethyl)-2-methylquinolines and related derivatives [J].

Badawey, ESAM ;

Kappe, T .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1997, 32 (10) :815-822

[2] A prodrug approach toward the development of water soluble fluoroquinolones and structure-activity relationships of quinoline-3-carboxylic acids [J].

Baker, WR ;

Cai, SP ;

Dimitroff, M ;

Fang, LM ;

Huh, KK ;

Ryckman, DR ;

Shang, X ;

Shawar, RM ;

Therrien, JH .

JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (19) :4693-4709

[3] Molecular iodine-catalyzed efficient and highly rapid synthesis of bis(indolyl)methanes under mild conditions [J].

Bandgar, BP ;

Shaikh, KA .

TETRAHEDRON LETTERS, 2003, 44 (09) :1959-1961

[4] Demethylation of 2,4-dimethoxyquinolines: the synthesis of atanine [J].

Jones, K ;

Roset, X ;

Rossiter, S ;

Whitfield, P .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2003, 1 (24) :4380-4383

[5]

Michnovic J.J., 1989, P R SOC ED, V12, P1571

← 1 →