GlyTouCan 1.0-The international glycan structure repository

被引:59
作者
Aoki-Kinoshita, Kiyoko [1 ,2 ]
Agravat, Sanjay [3 ]
Aoki, Nobuyuki P. [1 ]
Arpinar, Sena [4 ]
Cummings, Richard D. [5 ]
Fujita, Akihiro [1 ]
Fujita, Noriaki [2 ]
Hart, Gerald M. [6 ]
Haslam, Stuart M. [7 ]
Kawasaki, Toshisuke [8 ]
Matsubara, Masaaki [9 ]
Moreman, Kelley W. [4 ]
Okuda, Shujiro [10 ]
Pierce, Michael [4 ]
Ranzinger, Rene [4 ]
Shikanai, Toshihide [2 ]
Shinmachi, Daisuke [1 ]
Solovieva, Elena [2 ]
Suzuki, Yoshinori [2 ]
Tsuchiya, Shinichiro [1 ]
Yamada, Issaku [9 ]
York, William S. [4 ]
Zaia, Joseph [11 ]
Narimatsu, Hisashi [2 ]
机构
[1] Soka Univ, Fac Sci & Engn, Tokyo 1928577, Japan
[2] AIST, Glycosci & Glycotechnol Res Grp, Ibaraki 3058568, Japan
[3] Emory Univ, Dept Math & Comp Sci, Atlanta, GA 30322 USA
[4] Univ Georgia, Complex Carbohydrate Res Ctr, 220 Riverbend Rd, Athens, GA 30602 USA
[5] Harvard Univ, Sch Med, Dept Surg, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA
[6] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA
[7] Univ London Imperial Coll Sci Technol & Med, Fac Natl Sci, Dept Life Sci, London SW7 2AZ, England
[8] Ritsumeikan Univ, Res Ctr Glycobiotechnol, Kusatsu, Shiga 5258577, Japan
[9] Noguchi Inst, Tokyo 1730003, Japan
[10] Niigata Univ, Grad Sch Med & Dent Sci, Niigata 9518510, Japan
[11] Boston Univ, Sch Med, Dept Biochem, Ctr Biomed Mass Spectrometry, Boston, MA 02118 USA
基金
英国生物技术与生命科学研究理事会; 日本科学技术振兴机构;
关键词
D O I
10.1093/nar/gkv1041
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glycans are known as the third major class of biopolymers, next to DNA and proteins. They cover the surfaces of many cells, serving as the 'face' of cells, whereby other biomolecules and viruses interact. The structure of glycans, however, differs greatly from DNA and proteins in that they are branched, as opposed to linear sequences of amino acids or nucleotides. Therefore, the storage of glycan information in databases, let alone their curation, has been a difficult problem. This has caused many duplicated efforts when integration is attempted between different databases, making an international repository for glycan structures, where unique accession numbers are assigned to every identified glycan structure, necessary. As such, an international team of developers and glycobiologists have collaborated to develop this repository, called GlyTouCan and is available at http://glytoucan.org/, to provide a centralized resource for depositing glycan structures, compositions and topologies, and to retrieve accession numbers for each of these registered entries. This will thus enable researchers to reference glycan structures simply by accession number, as opposed to by chemical structure, which has been a burden to integrate glycomics databases in the past.
引用
收藏
页码:D1237 / D1242
页数:6
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