The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases

被引：49

作者：

Fanni, Daniela ^{[1
,2
]}

Gerosa, C. ^{[1
,2
]}

Nurchi, V. M. ^{[3
]}

Manchia, M. ^{[4
]}

Saba, L. ^{[5
]}

Coghe, F. ^{[6
]}

Crisponi, G. ^{[3
]}

Gibo, Y. ^{[7
]}

Van Eyken, P. ^{[8
]}

Fanos, V. ^{[9
]}

Faa, G. ^{[1
,2
,10
]}

机构：

[1] Univ Cagliari, UOC Sez Anat Patol, Dipartimento Sci Med & Sanita Pubbl, Via Osped 54, I-09124 Cagliari, Italy

[2] Univ Cagliari, UOC Anat Patol, AOU Cagliari, Cagliari, Italy

[3] Univ Cagliari, Dipartimento Sci Vita & Ambiente, Cagliari, Italy

[4] Univ Cagliari, UOC Psichiatria, Cagliari, Italy

[5] Univ Cagliari, UOC Radiol, AOU Cagliari, Cagliari, Italy

[6] Univ Cagliari, UOC Lab Anal, AOU Cagliari, Cagliari, Italy

[7] Hepatol Clin, Matsumoto, Nagano, Japan

[8] UZ Genk Reg Hosp, Dept Pathol, Genk, Belgium

[9] Univ Cagliari, UOC Terapia Intens Neonatale, AOU Cagliari, Cagliari, Italy

[10] Temple Univ, Philadelphia, PA 19122 USA

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 2021年 / 199卷 / 10期

关键词：

Magnesium; Trace element; Metal; Pregnancy; Fetal; Programming; FAMILIAL HYPOMAGNESEMIA; MG2+ HOMEOSTASIS; COPPER OVERLOAD; MAGPIE TRIAL; LEG CRAMPS; SULFATE; PREECLAMPSIA; IRON; HYPERCALCIURIA; DEFICIENCY;

D O I：

10.1007/s12011-020-02513-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Magnesium is an essential trace metal and a necessary factor for multiple biochemical functions in humans. Its role in biology is fundamental in over 600 enzymatic reactions implicated in protein synthesis, mitochondrial functions, neuromuscular activity, bone formation, and immune system competence. Magnesium status is relevant in fetal development during gestation and in the newborn growth during the perinatal period. Moreover, magnesium is able to influence fetal programming and disease presentation in childhood or adulthood. The aim of this review is to focus on this metal homeostasis, analyzing its normal values, the causes of hypomagnesemia, the interaction with drugs and other conditions, and the diseases associated with magnesium value alteration during pregnancy, in order to study its role in fetal programming of adult diseases. The data here reported clearly indicated the existence of a connection between magnesium status and human pathology starting from intrauterine life and extending into childhood and adulthood.

引用

页码：3647 / 3657

页数：11

共 86 条

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