Cytotoxic Aaptamines from Malaysian Aaptos aaptos

被引：45

作者：

Shaari, Khozirah ^{[1
]}

Ling, Kee Cheng ^{[1
]}

Rashid, Zalilawati Mat ^{[2
]}

Jean, Tan Pei ^{[1
]}

Abas, Faridah ^{[1
]}

Raof, Salahudin Mohd. ^{[1
]}

Zainal, Zurina ^{[1
]}

Lajis, Nordin Hj. ^{[1
]}

Mohamad, Habsah ^{[2
]}

Ali, Abdul Manaf ^{[3
]}

机构：

[1] Univ Putra Malaysia, Lab Nat Prod, Inst Biosci, Serdang 43400, Selangor, Malaysia

[2] Univ Malaysia Terengganu, Dept Chem Sci, Fac Sci & Technol, Kuala Terengganu 21030, Terengganu, Malaysia

[3] Univ Darul Iman, Fac Biotechnol, Kuala Terengganu, Terengganu, Malaysia

来源：

MARINE DRUGS | 2009年 / 7卷 / 01期

关键词：

Marine sponge; Aaptos aaptos; aaptaminoids; alkaloids; cytotoxicity; MARINE NATURAL-PRODUCTS; ANTINEOPLASTIC AGENTS; MISCELLANEOUS MECHANISMS; ANTIVIRAL ACTIVITIES; NERVOUS SYSTEMS; SPONGE; ISOAAPTAMINE; PHARMACOLOGY; ANTITUMOR; ANTITUBERCULOSIS;

D O I：

10.3390/md7010001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chloroform fraction of the crude methanolic extract. Detailed analysis by NMR and mass spectroscopy enabled their identification to be 3-(phenethylamino)demethyl(oxy)aaptamine and 3-(isopentylamino)demethyl(oxy) aaptamine. The cytotoxic activities of the three alkaloids were further evaluated against CEM-SS cells.

引用

页码：1 / 8

页数：8

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