Inhibition of Vascular Endothelial Growth Factor Receptor 3 Reduces Migration of Gastric Cancer Cells

被引：11
作者：
Lim, Jaeyoung [1 ]
Ryu, Ji Hyeon [2 ]
Kim, Eun-Jin [2 ]
Ham, Songhee [2 ]
Kang, Dawon [2 ]
机构：
[1] Gyeongsang Natl Univ, Sch Med, Inst Hlth Sci, Dept Pediat, Jinju, South Korea
[2] Gyeongsang Natl Univ, Sch Med, Inst Hlth Sci, Dept Physiol, Jinju, South Korea
来源：
CANCER INVESTIGATION | 2015年 / 33卷 / 08期
关键词：
Cell movement; Gastric neoplasms; Vascular endothelial growth factor C; Vascular endothelial growth factor receptor-3; LYMPH-NODE METASTASIS; VEGF-C; DOWN-REGULATION; FACTOR (VEGF)-C; TUMOR-GROWTH; LYMPHANGIOGENESIS; EXPRESSION; INVASION; PROLIFERATION; CARCINOMA;
D O I：
10.3109/07357907.2015.1047509
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Angiogenesis induced by proangiogenic molecules such as vascular endothelial growth factor (VEGF) is a key process in the progression and metastasis of gastric cancer. In this study, we investigated the role of VEGF-C/VEGF receptor 3 (VEGFR3) axis in cell proliferation and migration/invasion of human gastric cancer cells (hGCCs). VEGF-C did not enhance cell proliferation but increased cell migration/invasion by approximately approximate to 50% in hGCCs (AGS and SNU-484). MAZ51, a VEGFR3 inhibitor, reduced the VEGF-C-induced increase in migration/invasion by approximate to 30% (p < 0.05). These results suggest that VEGFR3 could be a therapeutic target for reducing the metastasis of gastric cancer cells.
引用
收藏
页码：398 / 404
页数：7
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