Overexpression of periostin is significantly correlated to the tumor angiogenesis and poor prognosis in patients with esophageal squamous cell carcinoma

被引：1
作者：
Wang, Wei [1 ]
Sun, Qi-Kai [2 ]
He, Yi-Fu [1 ]
Ma, Dong-Chun [3 ]
Xie, Ming-Ran [3 ]
Ji, Chu-Shu [1 ]
Hu, Bing [1 ]
机构：
[1] Anhui Med Univ, Anhui Prov Hosp, Dept Med Oncol, Hefei 230001, Peoples R China
[2] Anhui Med Univ, Anhui Prov Hosp, Dept Gen Surg, Hefei 230001, Peoples R China
[3] Anhui Med Univ, Anhui Prov Hosp, Dept Thorac Surg, Hefei 230001, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2014年 / 7卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Periostin; esophageal squamous cell carcinoma; angiogenesis; prognosis; ENDOTHELIAL GROWTH-FACTOR; GENE-EXPRESSION; CANCER CELLS; INVASION; MICROENVIRONMENT; PATTERNS; SURVIVAL; HYPOXIA; PROTEIN;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent studies have found that periostin (PN), as a kind of secreted glycoprotein, is closely related to the metastatic potential and prognosis of many kinds of tumors. This study aimed to examine the expression of PN in patients with esophageal squamous cell carcinoma (ESCC) and explore the relationship of PN expression with clinicopathologic factors, tumor angiogenesis and prognosis. The results showed that increased PN protein expression was prevalent in ESCC and was significantly associated with lymphatic metastasis (P=0.008), tumor differentiation (P=0.04), venous invasion (P=0.014) and TNM stage (P=0.001). Additionally, expression of PN was found to be an independent prognostic factor in ESCC patients. High expression of PN protein is closely correlated to the tumor progression and angiogenesis and poor survival of ESCC. Taken together, PN is a promising biomarker to identify individuals with poor prognostic potential and concludes the possibility of its use as a prognostic marker in patients with ESCC.
引用
收藏
页码：593 / 601
页数：9
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