Predictors of outcome in adults with BCR-ABL negative acute lymphoblastic leukemia treated with a pediatric-based regimen

被引：4

作者：

Brandwein, Joseph M. ^{[1
]}

Atenafu, Eshetu G. ^{[2
]}

Schuh, Andre C. ^{[1
]}

Yee, Karen W. L. ^{[1
]}

Schimmer, Aaron D. ^{[1
]}

Gupta, Vikas ^{[1
]}

Minden, Mark D. ^{[1
]}

机构：

[1] Univ Toronto, Princess Margaret Canc Ctr, Dept Med Oncol & Hematol, Toronto, ON, Canada

[2] Univ Toronto, Princess Margaret Canc Ctr, Dept Biostat, Toronto, ON, Canada

来源：

LEUKEMIA RESEARCH | 2014年 / 38卷 / 05期

关键词：

Acute lymphoblastic leukemia; Leukemia; Chemotherapy; Prognostic factors; ACUTE LYMPHOCYTIC-LEUKEMIA; MINIMAL RESIDUAL DISEASE; ALLOGENEIC TRANSPLANTATION; STANDARD-RISK; CHEMOTHERAPY; ADOLESCENTS; TRIAL; METAANALYSIS; REMISSION; SURVIVAL;

D O I：

10.1016/j.leukres.2013.10.025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We retrospectively evaluated the outcome of 156 adults age 17-60 with BCR-ABL negative acute lymphoblastic leukemia treated with a pediatric-inspired protocol. The CR rate was 93%; 5-year overall survival (OS) and disease-free survival were 66% and 70%, respectively. Age <34 years and low presenting WBC were independent predictors of favorable OS (p<0.0001). The 5 year OS of patients age <34 and 34-60 presenting with a low WBC were 85% and 57%, respectively; the 5 year OS for those presenting with a high WBC were 57% and 30%, respectively. Cytogenetics and phenotype were not independent predictors of OS. (C) 2014 Published by Elsevier Ltd.

引用

页码：532 / 536

页数：5

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