Low dilution procedures in solid-phase organic synthesis: Diels-Alder and Heck reactions

被引：14

作者：

Morphy, JR ^{[1
]}

Rankovic, Z ^{[1
]}

York, M ^{[1
]}

机构：

[1] Organon Labs ltd, Dept Med Chem, Newhouse ML1 5SH, Scotland

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 34期

关键词：

polmyer support; reagent concentration; solid-phase synthesis; low dilution; Diels-Alder; Heck reaction;

D O I：

10.1016/S0040-4039(02)01259-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of extremely low solvent volumes (2 muL or less per mg resin) results in significant increases in yield for both the Diels-Alder and Heck reactions on solid-phase compared to standard high dilution techniques. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：5973 / 5975

页数：3

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