Thyroid Cancer

被引:284
作者
Carling, Tobias [1 ]
Udelsman, Robert [1 ]
机构
[1] Yale Univ, Sch Med, Dept Surg, New Haven, CT 06510 USA
来源
ANNUAL REVIEW OF MEDICINE, VOL 65 | 2014年 / 65卷
关键词
surgery; lymph node dissection; radioactive iodine; targeted therapy; molecular diagnostics; NEEDLE-ASPIRATION BIOPSY; LYMPH-NODE DISSECTION; PROGNOSTIC-FACTORS; DOUBLE-BLIND; CARCINOMA; PAPILLARY; RISK; SURVIVAL; THERAPY; ASSOCIATION;
D O I
10.1146/annurev-med-061512-105739
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Thyroid cancer is rapidly increasing in incidence, but the mortality rate remains flat. Debate has arisen over the need to detect or treat most thyroid cancers early, given their favorable natural history. The appropriate extent of surgery for thyroid cancer is also controversial: some researchers advocate partial and others total thyroidectomy; some advocate prophylactic central cervical lymph node dissection, whereas others only rarely recommend lymphadenectomy. Although radioactive iodine is effective, its appropriate use and dosage remain controversial. In addition, molecular analysis of thyroid cancer is frequently used for diagnostic purposes involving preoperative fine-needle biopsy specimens as well as to define targetable pathways altered in the disease to guide clinical trials of drug therapy for advanced thyroid cancers.
引用
收藏
页码:125 / 137
页数:13
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