IBD across the age spectrum-is it the same disease?

被引:190
作者
Ruel, Joannie [1 ]
Ruane, Darren [1 ]
Mehandru, Saurabh [1 ]
Gower-Rousseau, Corinne [2 ]
Colombel, Jean-Frederic [1 ]
机构
[1] Icahn Sch Med Mt Sinai, Dept Med, Dr Henry D Janowitz Div Gastroenterol, New York, NY 10029 USA
[2] Lille Univ Nord France, Gastroenterol Unit, F-59000 Lille, France
关键词
INFLAMMATORY-BOWEL-DISEASE; ONSET CROHNS-DISEASE; POPULATION-BASED COHORT; GENOTYPE-PHENOTYPE CORRELATION; PEDIATRIC ULCERATIVE-COLITIS; ENVIRONMENTAL RISK-FACTORS; NORTHERN FRANCE 1988-1999; HEMATOPOIETIC STEM-CELLS; B-CELL; DENDRITIC CELLS;
D O I
10.1038/nrgastro.2013.240
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
IBD is a chronic disorder with disease onset ranging from early childhood to beyond the sixth decade of life. The factors that determine the age of onset currently remain unexplained. Is timing of occurrence a random event or is it indicative of different pathophysiological pathways leading to different phenotypes across the age spectrum? Over the past decade, several studies have suggested that the characteristics and natural history of IBD seem to be different according to age of onset. This heterogeneity suggests that the respective contributions of genetics, host immune system and environment to the aetiology and phenotype of Crohn's disease and ulcerative colitis are different across ages. Critical reviews that focus on differences characterizing IBD between age groups are scarce. Therefore, this Review updates the knowledge of the differences in epidemiology, clinical characteristics, and natural history of paediatric, adult and elderly-onset IBD. In addition, potential differences in host-gene-microbial interactions according to age are highlighted.
引用
收藏
页码:88 / 98
页数:11
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