MULTIPLE SCLEROSIS

被引：0

作者：

Miller, Elzbieta ^{[1
,2
]}

机构：

[1] III Gen Hosp Lodz, Neurorehabil Ward, Lodz, Poland

[2] Univ Bydgoszcz, Dept Chem & Clin Biochem, Bydgoszcz, Poland

来源：

NEURODEGENERATIVE DISEASES | 2012年 / 724卷

关键词：

BLOOD-BRAIN-BARRIER; OXIDATIVE STRESS; URIC-ACID; VITAMIN-D; RISK-FACTORS; INFLAMMATION; NEURODEGENERATION; OLIGODENDROCYTE; IMMUNE; MYELIN;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Multiple sclerosis (MS) is a chronic, complex neurological disease with a variable clinical course in which several pathophysiological mechanisms such as axonal/neuronal damage, demyelination, inflammation, gliosis, remyelination and repair, oxidative injury and excitotoxicity, alteration of the immune system as well as biochemical disturbances and disruption of blood-brain barrier are involved.(1,2) Exacerbations of MS symptoms reflect inflammatory episodes, while the neurodegenerative aspects of gliosis and axonal loss result in the progression of disability. The precise aetiology of MS is not yet known, although epidemiological data indicate that it arises from a complex interactions between genetic susceptibility and environmental factors.' In this chapter the brain structures and processes involved immunopathogenesis of MS are presented. Additionaly, clinical phenotypes and biomarkers of MS are showed.

引用

页码：222 / 238

页数：17

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