Ligand-Enabled γ-C-H Olefination and Carbonylation: Construction of β-Quaternary Carbon Centers

被引：183

作者：

Li, Suhua ^{[1
]}

Chen, Gang ^{[1
]}

Feng, Chen-Guo ^{[1
]}

Gong, Wei ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 14期

关键词：

CATALYZED INTRAMOLECULAR AMINATION; C(SP(3))-H BONDS; UNACTIVATED C(SP(3))-H; C(SP(2))-H BONDS; ARYLATION; ALKYLATION; SP(2); ACIDS; ACTIVATION;

D O I：

10.1021/ja501689j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Monoselective gamma-C-H olefination and carbonylation of aliphatic acids has been accomplished by using a combination of a quinoline-based ligand and a weakly coordinating amide directing group. The reaction provides a new route for constructing richly functionalized all-carbon quaternary carbon centers at the beta-position of aliphatic acids.

引用

收藏

页码：5267 / 5270

页数：4

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