Heart Failure With Normal Left Ventricular Ejection Fraction

被引：230

作者：

Maeder, Micha T.

Kaye, David M.

机构：

[1] Baker IDI Heart & Diabet Inst, Heart Failure Res Grp, Melbourne, Vic, Australia

[2] Alfred Hosp, Heart Ctr, Melbourne, Vic, Australia

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2009年 / 53卷 / 11期

基金：

瑞士国家科学基金会;

关键词：

heart failure; normal ejection fraction; diastolic function; pathophysiology; diagnosis; TISSUE DOPPLER-ECHOCARDIOGRAPHY; SOCIETY-OF-CARDIOLOGY; DIASTOLIC DYSFUNCTION; SYSTOLIC FUNCTION; NATRIURETIC PEPTIDE; ATRIAL-FIBRILLATION; CLINICAL CHARACTERISTICS; CARDIOVASCULAR HEALTH; FILLING PRESSURES; ANGINA-PECTORIS;

D O I：

10.1016/j.jacc.2008.12.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is estimated that approximately 50% of the heart failure population has a normal left ventricular ejection fraction, a complex broadly referred to as heart failure with normal left ventricular ejection fraction (HFNEF). While these patients have been considered in epidemiologic studies and clinical trials to represent a single pool of patients, limited more detailed studies indicate that HFNEF patients are a very heterogeneous group, with a number of key pathophysiologic mechanisms. This review summarizes and critically analyzes available data on the pathophysiology of HFNEF, placing it into context with a recently developed diagnostic algorithm. We evaluate the utility of commonly applied echocardiographic measures and biomarkers and integrate mechanistic observations into potential future therapeutic directions. (J Am Coll Cardiol 2009; 53: 905-18) (C) 2009 by the American College of Cardiology Foundation

引用

收藏

页码：905 / 918

页数：14

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