mRNA stability and the control of gene expression: Implications for human disease

被引：171
作者：
Hollams, EM
Giles, KM
Thomson, AM
Leedman, PJ
机构：
[1] Western Australian Inst Med Res, Lab Canc Med, Perth, WA 6000, Australia
[2] Western Australian Inst Med Res, Univ Dept Med, Perth, WA 6000, Australia
[3] Univ Western Australia, Perth, WA 6009, Australia
来源：
NEUROCHEMICAL RESEARCH | 2002年 / 27卷 / 10期
关键词：
mRNA stability; mRNA decay; cis-elements; RNA-binding proteins; disease; cancer;
D O I：
10.1023/A:1020992418511
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Regulation of gene expression is essential for the homeostasis of an organism, playing a pivotal role in cellular proliferation, differentiation, and response to specific stimuli. Multiple studies over the last two decades have demonstrated that the modulation of mRNA stability plays an important role in regulating gene expression. The stability of a given mRNA transcript is determined by the presence of sequences within an mRNA known as cis-elements, which can be bound by trans-acting RNA-binding proteins to inhibit or enhance mRNA decay. These cis-trans interactions are subject to a control by a wide variety of factors including hypoxia, hormones, and cytokines. In this review, we describe mRNA biosynthesis and degradation, and detail the cis-elements and RNA-binding proteins known to affect mRNA turnover. We present recent examples in which dysregulation of mRNA stability has been associated with human diseases including cancer, inflammatory disease, and Alzheimer's disease.
引用
收藏
页码：957 / 980
页数：24
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